Lu Wenwei Associate Researcher: Roy's Lactobacillus CCFM1072 and C CFM1040 with Treg cell regulation regulate allergies

Highlights:
C CFFM1072 and C CFM1040 significantly reduce airway inflammation, while DYNDL216, GDLZ105 and FZJTZ20M3 show no significant improvement
CCFM1072 and C CFM1040 induce Treg cell proliferation to further reduce airway inflammation
CCFM1072 Unlike C CFM1040, which regulates the gut microbiome, it is related to the proliferation of Treg cells
Lingzhi Li, Wenwei Lu, Wei Chen, et al., of the National Key Laboratory for Food Science and Technology, studied
Lactobacillus
(
L.
)
。 reuteri
)
effects of strains on respiratory inflammation, immune response, and gut microbiota.
the Roy's Lactobacillus C CFM1072 and C CFM1040 strains increased the number of Tregs in the spleen, reduced airway inflammation, lowered histamine, IL-17A, IL-5, and IL-13 levels in the lungs, and reduced the concentration of Th2-related immunoglobulins in the serum. Intestinal bacillus and metabolic analysis showed that CCFM1072 maintained the diversity of intestinal bacillus, promoting the growth of
Lactobacillus and
Bacteroides thetaiotaomicron
)
, increasing Acetate levels, and CCFM1040 reshaped the structure of the gut bacteria, in particular promoting the growth of
Bifidobacterium
, a growth-promoting bacteria associated with improved respiratory inflammation. In summary, the reduced effects of these two strains of Roy's Lactobacillus on respiratory inflammation depend in part on regulating the intestinal bacteria, although the mechanisms are different and also promote the proliferation of Tregs.
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Personal Profile
Lu Wenwei, Associate Research Fellow, School of Food, Jiangnan University, Master's Tutor
, Education
2009-2014, Ph.D., (Microbiology), (Shandong University)
2005 2009, Bachelor, (Biotechnology), (Shandong University)
research direction
research areas for intestinal micro-ecological and nutritional health: mainly engaged in functional probiotic resource mining and mechanism of action research;
article Lactobacillus reuteri CCFM1072 and CCFM1040 with the role of the Treg cells alleviate regulation airway via modulating gut microbiota in allergic asthma mice published online in Journal of Functional Foods.