Lu Xiaofeng research group of Jilin University: controllable preparation, synergistic enhancement of peroxidase like activity and highly sensitive detection of glutathione of polypyrrole nanotubes filled with femno 3 nanoparticles

Lead enzyme catalysis is a kind of catalytic reaction with high activity and selectivity between homogeneous and heterogeneous In recent years, the development of nanotechnology provides more and more opportunities for enzyme catalysis As a new type of catalyst, nano material mimic enzyme (nano enzyme) has the advantages of adjustable catalytic activity, excellent environmental stability, simple preparation and low cost compared with natural enzyme, so it has been developed rapidly Recently, Lu Xiaofeng group of Jilin University has made a series of important progress in the field of nano enzyme catalysis of conductive polymer matrix composite nanostructure materials, prepared a series of highly efficient conductive polymer matrix composite nano enzyme catalyst materials, found the synergistic enhancement effect of its enzyme like catalytic reaction, and applied it to the highly sensitive detection of a variety of target molecules (chem, 2018 , DOI: 10.1039/c8cc01574k ; Mater Chem Front , 2018 , 2 , 768-774; Sci China Mater , 2018 , DOI: 10.1007/s40843-018-9235-3; J Mater Chem C , 2017 , 5 , 7465-7471; Dalton Trans , 2017 , 46 , 11171-11179; Part Part Syst Charact 2017 , 34 , 1600233; ACS Appl Mater Interfaces 2016 ,8, 1041-1049）。 Prof Lu Xiaofeng, Professor of the school of chemistry, Jilin University, doctoral supervisor In 2003, he graduated from the school of chemistry, Jilin University with a bachelor's degree In 2007, he graduated from Jilin University with a Ph.D in polymer chemistry and physics, and then engaged in postdoctoral research at Washington University in St Louis, USA in 2008, he began to teach at the school of chemistry of Jilin University He has been supported by National Natural Science Foundation of China, Huo Yingdong education fund of Ministry of education and natural science fund of Jilin Province for many times He has published more than 150 SCI academic papers in prog Poly SCI., adv mater., small, chem Commun., J mater Chem A and other magazines His articles have been cited by SCI for more than 4000 times He co chaired the preparation of "organic nano functional materials - high voltage electrostatic spinning technology and nanofibers" (Wang CE, Lu Xiaofeng, etc.) Served as the vice chairman of the microfiber composite branch of China composite society In 2011, he won the second prize of Jilin Natural Science Academic Achievement Award (the first adult), and in 2015, he won the first prize of Jilin Science and Technology Award (NATURAL SCIENCE) (the second adult) The main research fields are: (1) electrospinning technology and nanofiber materials; (2) conductive polymer and its composite nanomaterials; (3) the application of nanomaterials in catalysis, energy and environment Leading scientific research achievements: the controllable preparation, synergistic enhancement of peroxidase like activity and highly sensitive detection of glutathione of polypyrrole nanotubes filled with femno 3 nanoparticles, the research team of Professor Lu Xiaofeng of Jilin University, has done a series of research work in the research of enzyme like catalysis of conductive polymer matrix composite nanostructures Recently, they prepared a new kind of nanoparticle filled polypyrrole nanotubes by electrospinning, in-situ gas polymerization and etching The structure of encapsulated nanoparticles in the nanotubes has the advantages of high specific surface area, low density and multiple active sites In the field of catalysis, the structure can also provide a nanometer scale reaction chamber for some continuous reactions, which can effectively avoid agglomeration of active components and additional separation and purification process In addition, the inorganic nanoparticles encapsulated in the conducting polymer nanotubes showed a strong synergistic enhancement effect on the peroxidase like catalytic reaction Femno 3 nanofibers were prepared by electrospinning and high temperature calcination This material has certain oxidation property and can polymerize pyrrole monomer in acid condition As a template and oxidant, femno 3 nanofibers can be etched at the same time of in-situ polymerization of conducting polymers The fibers gradually decompose into nanoparticles, with the formation of polypyrrole shell By changing the reaction time of gas-phase polymerization, the thickness of polypyrrole shell and the filling density of femno 3 nanoparticles in the lumen can be effectively controlled (Fig 1) This method of in-situ etching and polymerization at the same time for the preparation of inorganic nanoparticles in conducting polymer nanotubes has universality, and the preparation is simple, low cost, easy to promote, and can be widely used in many fields Fig 1: SEM, TEM and schematic diagram of different gas phase polymerization time: A1-A3) 30 min, b1-b3) 60 min, C1-C3) 120 min, D1-D3) 180 min (source: chem Commun., 2018, Doi: 10.1039/c8cc01574k) next, the author explored the peroxidase like catalytic properties of the material It can be seen that the catalytic activity of femno 3 nanofibers is not outstanding, but the catalytic properties of the material are significantly enhanced after composite with conductive polymers The composite with reaction time of 120 min has a typical nano particle structure in the tube, which shows the optimal enzyme like activity, and its catalytic activity is five times higher than that of femno 3 nanofiber substrate (Fig 2) Figure 2: peroxidase like catalytic property test (source: chem Commun., 2018, DOI: 10.1039/c8cc01574k) Using the inherent peroxidase like property of the material, the author explored its application in the highly sensitive detection of glutathione (GSH) The detection limit of GSH was as low as 36 nm, which was better than most reports based on enzyme-like catalytic reaction system In comparison with other amino acids and ions, the material also showed good selectivity In addition, the GSH detection system can also be used in the actual detection of human serum samples, with the advantages of high accuracy and good repeatability, showing its potential application in the field of biological detection Figure 3: GSH detection limit test (source: chem Commun., 2018, DOI: 10.1039/c8cc01574k) is supported by NSFC Chi Maoqiang, a doctoral student, is the first author, and Professor Lu Xiaofeng is the corresponding author Nowadays, people and scientific research have been paid more and more attention in the economic life China has ushered in the "node of science and technology explosion" Behind the progress of science and technology is the work of countless scientists In the field of chemistry, in the context of the pursuit of innovation driven, international cooperation has been strengthened, the influence of Returned Scholars in the field of R & D has become increasingly prominent, and many excellent research groups have emerged in China For this reason, CBG information adopts the 1 + X reporting mechanism CBG information, chembeango app, chembeango official microblog, CBG wechat subscription number and other platforms jointly launch the column of "people and scientific research", approach the domestic representative research group, pay attention to their research, listen to their stories, record their demeanor, and explore their scientific research spirit.