Lymph node-like structures found in brain cancer patients can help fight tumors

On July 5th, researchers from Uppsala University in Sweden published a new study in the journal Nature Communications and found that lymph node-like structures near the tumor in patients with brain cancer, where immune cells can be activated to attack the tumor
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They also found that in a mouse model, immunotherapy enhanced the formation of these structures

immunity

This study describes the lymph node-like structures they found in the brain where T lymphocytes can be activated
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This study reveals the pleiotropic effect of αCD40 therapy in gliomas, and reveals that immunotherapy can regulate the formation of TLS in the brain to regulate immune responses in the future

Glioma is a fatal brain tumor with a poor prognosis
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One reason brain tumors are very difficult to treat is that our immune system is designed to detect and destroy foreign cells including cancer cells, but due to obstacles around the brain, it cannot easily reach the tumor site

In order to fight against developing tumors, killer immune cells such as T lymphocytes must be activated and prepared in the lymph nodes in the body, and then go to the tumor site to effectively kill the cancer cells
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Due to obstacles around the brain, it is a challenging process for T lymphocytes to reach the tumor

"It is very exciting to find for the first time that there are lymph node-like structures in glioma patients
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These structures are called tertiary lymphatic structures (TLS), and they do not exist in healthy people

Tumor immunity

The researchers also showed that the formation of TLS in the brain can be induced by an immunotherapy in glioma mice
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In fact, when they treated mice with an immunostimulatory antibody called αCD40, the formation of TLS was enhanced, and it always occurred near the tumor

The article concludes that systemic αCD40 treatment results in reduced cytotoxic T cell responses and reduced CPI in preclinical glioma models
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A potentially limiting study indicates that the preclinical glioma model used has a high mutation burden and is more sensitive to immune checkpoint blockade than most de novo human gliomas

This work also shows that TLS is present in glioma patients and immunotherapy can modulate these structures in a mouse glioma model
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The importance of TLS in response CPI is unknown and needs further investigation

The discovery that TLS in the brain can be manipulated therapeutically opens up the possibility of triggering or suppressing immune responses, which have a broader impact on the brain, central nervous system malignancies and autoimmune disease systems
.
The discovery that TLS in the brain can be manipulated therapeutically opens up the possibility of triggering or suppressing immune responses, which have a broader impact on the brain, central nervous system malignancies and autoimmune disease systems
.

Anna Dimberg, who led the research, said: "Understanding that immunotherapy can regulate the formation of tertiary lymphatic structures in the brain provides an exciting opportunity to find new ways to regulate the anti-tumor immune response in gliomas
.
"

"Understanding that immunotherapy can regulate the formation of tertiary lymphatic structures in the brain provides an exciting opportunity to find new ways to regulate the anti-tumor immune response in gliomas
.
" "Understanding that immunotherapy can regulate the tertiary levels of the brain The formation of lymphatic structure provides an exciting opportunity to find new ways to regulate the anti-tumor immune response in glioma
.
"

αCD40 is currently being used to treat brain tumors in some clinical trials
.
In a study published now, researchers have found that although αCD40 promotes the formation of TLS, it also counteractly inhibits the tumor-killing ability of T lymphocytes
.
Therefore, this study provides important insights into the various effects of αCD40 therapy
.

In a study published now, researchers have found that although αCD40 promotes the formation of TLS, it also counteractly inhibits the tumor-killing ability of T lymphocytes
.
Therefore, this study provides important insights into the various effects of αCD40 therapy
.
In a study published now, researchers have found that although αCD40 promotes the formation of TLS, it also counteractly inhibits the tumor-killing ability of T lymphocytes
.
Therefore, this study provides important insights into the various effects of αCD40 therapy
.

 

Reference materials:

Luuk van Hooren, Alessandra Vaccaro, Mohanraj Ramachandran, Konstantinos Vazaios, Sylwia Libard, Tiarne van de Walle, Maria Georganaki, Hua Huang, Ilkka Pietilä, Joey Lau, Maria H.
Ulvmar, Mikael CI Karlsson, Maria Zetterling, Sara M.
Mangsbo, Asgeir S.
Jakola, Thomas Olsson Bontell, Anja Smits, Magnus Essand and Anna Dimberg, Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma, 5 July 2021, Nature Communications .
DOI: 10.
1038/ s41467-021 -24347-7

Nature Communications DOI: 10.
1038/ s41467-021-24347-7 Leave a message here