"Made in China" entered the global vaccine supplier list

Source: after unremitting efforts on April 22, 2016, the supervision, development and production of Chinese vaccine products have been widely recognized internationally, and "made in China" has entered the global vaccine supplier list Up to now, two companies in China have passed who pre certification In May this year, Hualan biological meningococcal vaccine will be subject to the on-site verification of who; prior to that, in 2013, Chengdu Biological live attenuated encephalitis vaccine under China Biotechnology Co., Ltd passed the who's vaccine pre certification, which is also the first vaccine product in China to pass the who's pre certification, realizing the "zero breakthrough" of China's vaccine internationalization On April 25, when the National Children's vaccination day came, Dr lance, who's China Representative Office's expanded immunization program, said in an interview that it is a prerequisite for vaccine manufacturers to obtain the vaccine procurement of the United Nations and other international organizations to pass the WHO vaccine pre certification Vaccine is the most powerful "weapon" for prevention and control of infectious diseases Vaccination is one of the most effective and influential measures for public health prevention and control, and also the most powerful "weapon" for prevention and control of infectious diseases in various countries Through vaccination, smallpox has been successfully eliminated in the world; most countries and regions have blocked the transmission of wild poliovirus; the incidence, disability and death caused by diphtheria, pertussis, tetanus and measles have also declined significantly in the world Yu Wenzhou, chief physician of the immunization planning center of China CDC, said that China began to carry out planned immunization in 1978, vaccinating against six diseases with "four vaccines" In 1988, 1990 and 1996, the vaccination rates of BCG, polio, DPT and measles reached 85% respectively in provinces, counties and townships In 2002, the hepatitis B vaccine for newborns was included in the national immunization plan; in 2007, the national immunization plan was expanded to include hepatitis A vaccine, encephalitis B vaccine, etc in the national immunization plan, and 14 national immunization plan vaccines were used to prevent 15 diseases At present, the vaccination rate of the national immunization program with villages as the unit has reached 90% Through the implementation of vaccination, smallpox was eliminated in China, and the goal of polio free was achieved in 2000 After the promotion of hepatitis B vaccination for newborns, the HBsAg carrying rate of children under 5 years old dropped from 9.67% in 1992 to 0.32% in 2014, a drop of 97% More than 30 million people were reduced in chronic hepatitis B infection due to hepatitis B vaccination The incidence rate incidence rate incidence rate of incidence of measles in 2015 was 3.11/10 million, and dropped to a low level The reported incidence of epidemic encephalitis B was reduced to 0.046/10 million, the incidence rate of epidemic cerebrospinal meningitis dropped to less than 0.01/10, the incidence of pertussis reported was 0.49/10 million, and 22667 cases of hepatitis a reported in 2015, with an incidence rate of 1.66/10 million, and before the inclusion of national immunization program (5.98/10 million) Compared with that, it decreased by 72.2% It's not "once and for all" that the vaccine passed the WHO pre certification It is understood that in 1987, in order to ensure the safety of vaccines purchased by United Nations agencies from different channels, who launched the "vaccine pre certification system" After that, if the vaccine products of enterprises want to enter the United Nations procurement catalogue, they must go through the "pre certification" of who, and if enterprises want to apply for the pre certification to who, there is an important prerequisite, that is, the vaccine regulatory system of the country must pass the approval of who On the list of vaccine products on the WHO website, about 30 enterprises from the United Kingdom, the United States, France, Germany, Brazil, Cuba, Bulgaria, India and other countries have passed the pre certification and provided vaccine products to United Nations agencies Lance said that in the past six years, who has carried out two in-depth independent evaluations on China's vaccine production supervision, both of which show that China's regulatory system has met who standards After passing who's vaccine pre certification, the United Nations procurement agency can list this product in the procurement catalogue More importantly, due to the quality, production capacity and price advantages of vaccine products made in China, it will provide strong support for children in developing countries to avoid related diseases However, Lance also pointed out that it is not "once and for all" for the vaccine to pass the WHO pre certification, and the who will periodically review the vaccine regulatory system Yang Xiaoming, director of the national joint vaccine Engineering Technology Research Center, chief scientist of the vaccine project of the national "863" plan, and chairman of China Biotechnology Co., Ltd., said that vaccine is a special product, which is mainly used for disease prevention of healthy people, and the state's requirements for its safety are put first Generally, it takes at least 8 years or even 20 years for a vaccine to be developed and put on the market In the long period of R & D, there are a series of strict management Before the vaccine is registered, it needs to go through strict animal experiment and clinical research Before the vaccine is put on the market, it needs to implement strict batch issuing system Before, during and after the vaccination, it has complete, scientific and normative requirements As the "national team" of vaccine production, China Bio group began in 1919, which is about to usher in the "centenary of birth" It has been undertaking the research, development and production of national first-class vaccines At present, about 70% of the first class vaccine and about 40% of the two class vaccine are produced and provided by China biological group It is understood that Japanese encephalitis is a disease transmitted by mosquito bites, which will lead to brain inflammation The seasonal prevalence of Japanese encephalitis is a major public health problem in the world Because there is no special treatment for JE, vaccination is an effective preventive measure Yang Xiaoming said that the live attenuated encephalitis B vaccine, which has passed the WHO vaccine pre certification, is a vaccine independently developed and has independent intellectual property rights in China It was jointly developed by the research team led by academician Yu Yongxin of CFDA and the product development team of Chengdu Institute of biological products The vaccine 1998 Approved by the former Ministry of health in, it has been used more than 600 million times so far, providing effective immune protection for hundreds of millions of children Previously, through the procurement bidding process of UNICEF, Sinopharm Chengdu Co., Ltd delivered 1789000 live attenuated JE vaccine to Laos on February 15, 2015, becoming the first Chinese vaccine purchased by UNICEF and GAVI For the first time, vaccines from China have been used to promote epidemic control in low - and middle-income countries.