Magic! Nature: Eating spicy food can mobilize your hematopoietic stem cells or help treat blood diseases

Hematopoietic stem cells (HSCs) are adult stem cells in the blood system and are commonly found in bone marrow, exosome and umbilical cord blood.
In a person's lifetime, HSC needs to supplement the mature cellular components of the blood system in a timely manner according to the physiological needs of the body, for example, in the state of injury, inflammation and other stress, it needs to regulate and maintain the physiological balance of the various cellular components of the blood system in the body.
HSC has the potential to differentiate into various blood cells, making it the first choice for treating blood system and autoimmune diseases.
, however, the detailed mechanism for mobilizing the HSC remains unknown.
recently, researchers from the Albert Einstein College of Medicine published an article in Nature entitled Nociceptive nerves, "Regulation haematopoietic stem cell mobilization", which found that damaged nerves mobilize hematopoietic stem cells, providing new directions for stem cell transplantation and the treatment of blood diseases.
previous studies have shown that the mobilization of HSC is regulated by nerves.
, the researchers first investigated the total nerve density in the bone marrow of mice using immunofluorescence imaging, and found that both the injury nerve and the sensory nerve were projected, and that the percentage of damaged nerves was as high as 77%.
to further determine the mechanism of effect of the two nerves, the researchers individually cut off one of the nerves and found no effect on the amount of HSC in the bone marrow, but at the same time cut off both, the number of HSCs decreased significantly.
As it decreases, the amount of HSC is restored by continuously increasing the calcitonin gene-related peptide CGRP (neurotransmitters secreted by injury neurons) or β-adrenaline-energy-energy exciters (neurotransmitters secreted by sensory neurons).
suggests that the injury nerve and the sensory nerve together form a network of nerve closures that control the formation of HSC.
the promotion of HSC mobilization by these injury neurons has been shown that G-CSF (granulocyte collection stimulation factor) can mobilize HSC from the bone marrow into the bloodstream.
, the researchers found that the number of HSCs was not affected, but the mobilization and migration capacity of HSCs was reduced.
suggests that the lack of injury neurons selectively affects the outflow of HSC and requires injury neurons to allow the G-CSF-induced HSC to enter the bloodstream from the bone marrow.
, the researchers explored the role of CGRP in HSC mobilization.
found that CGRP therapy significantly increased the number of HSCs mobilized by G-CSF, indicating that G-CSF-induced HSC mobilized neuropeptide CGRP regulation derived from injury nerves.
further exploration of the CGRP-promoting HSC outflow process and the discovery of CGRP subjects consisting of CALCRL and RAMP1 indicate that CGRP, through its heterogeneic binary complex, RAMP1-CALCRL, actes on hematostocytes, thereby facilitating HSC outflow.
CGRP's active role in HSC mobilization of signal pathogenic nerves by the same-sourced subject, RAMP1-CALCRL, induced by HSC to mobilize injury neurons, led researchers to venture to speculate that the intake of spicy foods might trigger HSC mobilization in the bone marrow (the intake of spicy foods triggers the active activity of injury neurons).
, the researchers fed mice a diet containing capsaicin, and the results showed that the number of G-CSF-induced HSCs in mice that ate spicy foods was significantly higher than in mice fed regular food.
the effects of a capsaicin-containing diet on HSC mobilization in mice, the researchers wrote at the end of the article that it is possible to mobilize hematopoietic stem cells in a person if they eat 10 Mexican red peppers a day for four days in a pair of days.