Magic skin regeneration ability comes, 2020 "mouse" you are the most beautiful

Fibrosis is a medical concept, which can occur in many organs The main pathological changes are the increase of fibrous connective tissue and the decrease of parenchymal cells in organ tissue Continuous progress can lead to organ structural damage and functional decline, even failure, which seriously threatens human health and life Recently, researchers from various countries, such as junghae Yoon, Timothy J Garrett from the University of Florida and the Korean Institute of basic science, analyzed and compared the proteomics of cicatricial skin regeneration of African hairy mice and mice, and determined several experimental methods to reduce mammalian fibrosis The study is published in the journal scientific reports At present, a lot of information about the differences between African hairy mice and mice comes from cell and genetic analysis Most of the protein participation is not through direct observation In order to study the ability of regenerating new skin tissue, a more comprehensive proteomic study is needed The researchers compared the proteome of untreated and injured mice with that of African hairy mice, both qualitatively and quantitatively, to identify proteins that are beneficial to scar free healing About 2000 kinds of proteins were identified, most of which were expressed at similar levels in hairy mice and mice, but the levels of ubiquitin ligase, phosphorylated protein, protease, immunomodulator and macrophage marker were significantly different Protein degradation and synthesis enhancement are the main mechanisms of skin regeneration in African hairy mice, especially ubiquitination and phosphorylation may play a key role in regulating the signal pathway of tissue repair Protein protein interaction to predict the discovery of DEPs in African hairy mice and mice researchers identified the protein and its expression level in skin tissue extracts through 0, 3, 5, 7 and 14 days of unlabeled quantification These stages were selected as key time points to determine the protein differences that may lead to regeneration and scar formation because the wound is re epithelizing and granulation tissue is being established It was found that Wnt pathway plays an important role in controlling the interaction of epidermal stem cell regeneration, dermal papilla demand and epidermal activation in migratory wound In addition, the extracellular matrix (ECM) protein profiles of African hairy mice and mice were also different The researchers said that there are many differences in protein expression between the regeneration and repair of African hairy mice and the fibrosis and repair of mice It is important to design and study in the future to determine whether there are special genes or metabolic components that can trigger regeneration and repair, and improve the common fibrotic situation in mammals after injury Reference source: doi.org/10.1038/s41598-019-56823-y jienigui statement: this view is only on behalf of the author, not on behalf of the position of yaozhi.com, welcome to exchange and supplement in the message area; if you need to reprint, please be sure to indicate the author and source of the article.