Magnesium sulfate injection

Introduction: magnesium sulfate is used as a fertilizer in agriculture because magnesium is one of the main components of chlorophyll What about magnesium sulfate injection? Come and have a look with you! Magnesium sulfate is easily soluble in water and can't be absorbed by oral administration Magnesium sulphate powder can be applied to reduce swelling, to treat swelling after limb trauma, to help improve rough skin, etc What about magnesium sulfate injection? Let's introduce the small edition of Baibai safety net! Magnesium sulfate injection is a colorless clear liquid Intramuscular injection, 1g once, intravenous drip, diluted with 5% glucose injection to 1% concentration before use, 1-2.5g once Too fast intravenous drip can cause blood pressure drop and apnea Anticonvulsant Pharmacology and Toxicology Magnesium ion can inhibit the activity of the central nervous system, the release of acetylcholine from the motor nerve muscle joint, block the conduction at the neuromuscular junction, reduce or relieve the muscle contraction, at the same time, it can relax the vascular smooth muscle, dilate the peripheral blood vessels of spasm and reduce the blood pressure, so it can prevent and treat eclampsia, and also inhibit the contraction of the uterine smooth muscle, It can be used to treat premature delivery After intramuscular injection of pharmacokinetics, it took effect 20 minutes, and intravenous injection almost immediately The effect lasted for 30 minutes, and the effective blood magnesium concentration in the treatment of preeclampsia and eclampsia was 2-3.5mmol/l, and the effective blood magnesium concentration in the treatment of preterm delivery was 2.1-2.9mmol/l, with great individual difference Both intramuscular injection and intravenous injection, drugs are excreted by the kidney, and the rate of excretion is related to the concentration of blood magnesium and glomerular filtration rate It can be used as anticonvulsant Commonly used in pregnancy hypertension Lowering blood pressure, treating preeclampsia and eclampsia, also used to treat preterm birth The first dose for the treatment of moderate and severe pregnancy hypertension, preeclampsia and eclampsia was 2.5-4g, diluted with 20 ml 25% glucose injection, intravenous injection slowly within 5 minutes, and then maintained 1-2g per hour The total amount of 24 hours was 30g, which was monitored according to the knee tendon reflex, the number of breaths and urine volume 2 The dosage and method of treatment of preterm birth are similar to those of treatment of pregnancy hypertension The first loading is 4G After dilution with 20ml of 25% Guosong injection, intravenous injection will be slow within 5 minutes, and then 60ml of 25% magnesium sulfate injection and 1000ml of 5% Guosong injection will be intravenous drip The speed is 2G per hour until 2 hours after uterine contraction stops, and then oral adrenergic receptor agonists will be maintained 3 Intramuscular injection or intravenous medication for children with convulsion: 0.1-0.15g/kg each time, dilute the product into 1% solution with 5% - 10% glucose injection, intravenous drip or dilute into 5% solution, and inject slowly 25% solution can be used for deep intramuscular injection Generally, only intramuscular injection or intravenous medication is used in pediatrics, which is safe Side effects 1 Intravenous magnesium sulfate often causes red tide, sweating, dry mouth and other symptoms Rapid intravenous injection can cause nausea, vomiting, panic, dizziness, and individual nystagmus Symptoms of slow injection speed can disappear 2 The renal function is not complete, the dosage is large, and the accumulation of blood magnesium can occur When the concentration of blood magnesium reaches 5mmol / L, the excitability of muscle can be inhibited, the sensory response is slow, the knee tendon reflex disappears, and the respiration begins to be inhibited When the concentration of blood magnesium reaches 6mmol / L, the respiratory arrest and arrhythmia can occur, the heart conduction block, the concentration further increases, and the heartbeat can be stopped 3 Continuous use of magnesium sulfate can cause constipation, and some patients may have paralytic ileus, which will be improved after drug withdrawal 4 A few cases of hypocalcemia were found 5 Magnesium ion can freely pass through the placenta, resulting in hypermagnesemia of the newborn, which is characterized by low muscle tension, poor sucking power, inactivity, no loud crying, and a few respiratory depression 6 A few pregnant women have pulmonary edema Note 1 Before the application of magnesium sulfate injection, the renal function should be checked If the renal function is not complete, the dosage should be reduced 2 It should be used with caution or not when there is myocardial damage or heart conduction block 3 Before and during each application, the knee tendon reflex should be checked regularly, the number of breaths should be measured, the amount of micturition should be observed, and the knee tendon reflex obviously weakened or disappeared after blood sampling and magnesium concentration inspection, or the number of breaths should be less than 14-16 times per minute, the amount of urine per hour should be less than 25-30ml or less than 600ml after 24 hours, and the drug should be stopped in time 4 In case of chest distress, chest pain and shortness of breath, auscultation shall be carried out in time, and chest X-ray film shall be taken if necessary, so as to detect pulmonary edema as soon as possible 5 In case of acute magnesium poisoning, it can be saved by intravenous injection of calcium agent, and 10 ml of 10% calcium gluconate injection can be injected slowly 6 It is not suitable to use it together with adrenergic receptor agonists, such as ritodrine, or it will cause cardiovascular adverse reactions The above is a small edition for you to introduce some of the contents of magnesium sulfate injection, I hope to help you! 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