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In a large study published July 17 in Nature Communications, an international team of researchers from the University of Edinburgh and the Max Planck Institute for Aging in Germany found that maintaining healthy levels of iron in the blood may be key to improving aging and prolonging life.
there are many studies on longevity, but the scale of the new study is very large, covering genetic information from more than 1 million people in three public databases. For large enough samples, the Genome-wide Association Study (GWAS) on aging patterns has the potential to identify genes and biological pathways associated with the human aging process.
addition, the study measured three key indicators of aging: longevity (natural life expectancy), healthy life expectancy (disease-free life expectancy), and high life (ultra-senior life expectancy).
the entire GPAS analysis, the researchers identified 10 gene base effects on the three key indicators, most of which were associated with cardiovascular disease, and some of which altered their gene expression activity with age. Finally, the researchers identified a path that deserves further study: hemolystycin metabolism, or iron metabolism. In short, high levels of iron in the blood seem to increase the risk of early death.
Paul Timmers, a data analyst at the University of Edinburgh and co-author of the study, said: "These findings suggest that high levels of iron in the blood reduce healthy life expectancy, while controlling iron levels can prevent age-related damage. We speculate that these findings may explain why iron-rich red meat in the diet is associated with age-related diseases, such as heart disease. Although
correlation does not necessarily mean causation, the researchers used Mendel randomization to reduce bias and try to infer causation in the data.
researchers note that genes are thought to have an impact on life expectancy and healthy life expectancy by about 10 percent, making it difficult to pinpoint genes from all other relevant factors, such as smoking or drinking habits. With this in consideration, one of the advantages of this new study is its size and scope.
addition to genetic factors, iron in the blood is mainly controlled by diet and has been shown to be associated with many age-related diseases, including Parkinson's and liver disease. As you get older, it also affects your body's ability to fight infection.
evidence that "iron overload" or the resulting in the proper decomposition of iron can affect people's life expectancy and their health in later life. This latest study proves it.
"Our ultimate goal is to find out how aging is regulated and to find ways to improve health in the process," said Study Co-author Joris Dierina of the Max Planck Institute for Aging. "
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