Make up too much nutrition, bowel cancer or come knocking on the door.

Original title: make up too much nutrition, bowel cancer or to knock on the door
Spring Festival holiday to eat and eat to continue to the 15th of the month, but also immersed in the feast of people to be vigilant, eat into the various nutrients, is likely to give birth to cancer in your intestines.
", a key gene in the cancerous process of tumors, can malignantly proliferate by promoting a large intake of surrounding nutrients by tumor cells. As a result, excessive nutrient intake, especially foods rich in serine and methionine, is more likely to cause bowel cancer. "Not long ago, a new study on diet and health by Professor Li Menghong of the Sixth Hospital affiliated with Sun Yat-sen University found that the old saying of "a hundred sick people with a mouthful" was confirmed.
researchers called for more vegetables, fruits, less meat, can effectively prevent the occurrence of tumors. Professor Li Menghong's team published the findings in the journal Cell Research, which also brings new ideas for bowel cancer treatment.the incidence of colorectal cancer in China is increasing year by year
colorectal cancer is the third highest malignant tumor in the world, with high incidence, high mortality rate, low cure rate and so on. Public data show that in recent years, the incidence of colorectal cancer in China has been increasing year by year, and among all malignant tumors in China, the total morbidity and mortality rate of the disease ranks 5th. In some big cities, the incidence of colorectal cancer has even jumped to second place, after lung cancer.
" colorectal cancer pathogenesis is complex, long-term, need to be observed in many links as a whole. According to Li Menghong, "The early diagnosis rate of the disease is low, most patients are found to be in the middle and late stages, chemotherapy has become the main treatment." However, traditional chemotherapy side effects are large, the prognosmation is not ideal. "
with the rise of molecularly targeted therapy, this treatment is becoming a new option for tumor therapy. As one of the more widely studied targeted drugs, the efficacy of sitoxysyddant is quite good, but there are limitations. "Sitoxidon is effective and reactive for some subsexual bowel cancers, but sitoxysyfen is still ineffective in some people." Li Menghong said.
in order to find out the cause of sitoxy single anti-drug resistance, Li Menghong's team started from the clinical, through sequencing and other large histological methods to identify the key gene of tumor cancer process ILF3.
is ILF3? "The ILF3 gene is an mRNA binding protein that is a key gene in the cancerous process of tumors. " Li Kai, the first author of the above-mentioned research paper, introduced. They targeted the ILF3 gene, and shunned melons with new research.Eating too much nutrition will "add bricks and mortar" to tumor cells
" the key gene ILF3 can promote tumor cells, more greedy intake of surrounding nutrients, especially glucose, serine, etc., for tumor cells 'bricks and mortar', promote the malignant proliferation of tumors. Li Kai said. In other words, eating too much, the more nutritious you eat, especially foods rich in serine and methionine, will promote the development and development of cancer.
To eat" to pay attention to nutrition, can eat too much nutrition but will induce colorectal cancer, Li Menghong team revealed the reasons behind: the study found that the serine synthesis pathline can be over-activated by ILF3, so as to provide energy supply to cells, nucleotide synthesis raw materials and reducing force, inhibit oxidative stress, promote the malignant growth of tumor cells.
In addition to revealing that excessive nutrient intake, especially foods rich in serine and methionine, is more likely to induce bowel cancer, the study also reveals for the first time the function of ILF3 in maintaining the metabolism of serine in colorectal cancer cells and promoting colorectal cancer malignancy. At the same time, the key role and regulatory mechanism in the progress process, and the in vivo experiments have proved that ILF3 can be used as a new prognostic predictor and potential therapeutic target for colorectal cancer, and its inhibitors have potential drug development value.
menghong team through upstream analysis found that the ILF3 gene may be the cause of bowel cancer, the first-line drug sytoxidoxe resistance factors. Targeting this gene, as well as downstream metabolic path paths, may provide new thinking for future solutions to Sytoxidoxy resistance.to develop inhibitors that both ensure nutrition and fight tumors
current colorectal cancer treatment is mainly prevention, emphasizing early prevention and screening. There are many factors that induce colorectal cancer, including genetics, environment, etc.
"at home and abroad have been reported colorectal cancer family genetic reports, colorectal cancer patients in the blood relatives of the death of the disease than the general increase. Some colorectal adenomas, such as multiple familial adenomas, are a common chromosomal-explicit genetic disease with a prevalence rate of up to 50% in the family, and if not treated, there is a risk of colorectal cancer after the age of 10. Too much fried and pickled food is also one of the triggers of colorectal cancer, Li said.
study found that the incidence of colorectal cancer was associated with high fat consumption in food. In addition, it may also be related to changes in trace elements, living habits, etc.
rapidly developing socio-economic environment, people's diet structure is becoming more and more high-fat and high-protein, more prone to cancer. Li Kai suggested that a balanced diet, eat more fruits and vegetables, enhance immunity, will be conducive to cancer treatment. He pointed out that the occurrence of bowel cancer and eating habits are closely related, eat more fresh fruits, vegetables and other foods rich in carbohydrates and fiber, appropriately increase the proportion of staple foods, eat less high-fat foods, especially to reduce animal fat intake, because high-fat, high-protein, low-fiber food produced more carcinogens, stay in the colorectal for a long time, will increase the incidence of colorectal cancer. This is one of the reasons why bowel cancer is higher in western developed countries than in developing countries.
" our study further confirms the role of amino acid metabolism pathlines in promoting cancer, and we hope that in the future we can achieve specific target cancer cell amino acid metabolism, inhibit cancer cells over-absorption of the body's nutrients and affect normal cell functioning. Li Kai said he hopes to develop some amino acid metabolism-related primary cancer gene inhibitors, so as to ensure the nutritional intake of patients at the same time, the use of inhibitors to inhibit the tumor cells exuberant amino acid metabolism.to be healthy, three-point hunger and chills
Last year, The Lancet published a survey of the relationship between diet and health in 195 countries and territories. Studies show that 110 million people died from diet and 2.55 billion were disabled in 2017. Among them, high salt diet, low grain intake, low fruit intake and other three dietary factors are the main factors leading to death. Among noncommunicable chronic diseases, the diseases most associated with diet are cardiovascular disease, type 2 diabetes, and tumors.
, a member of the Chinese Academy of Engineering, made it clear at a forum on food and health that tumor formation is related to overeat. He says tumor formation is associated with abnormal growth of telomeres. When the human body due to viruses, bacteria, psychology, oversleed and other problems caused by inflammation, the resulting oxidation damage will make telomeres shorten rapidly, telomerase is activated, which may lead to abnormal growth of telomeres;
" long-term satiety can lead to premature brain aging. Fullness induces the active growth factor of fibroblasts in the brain, which is the cause of cerebral arteriosclerosis, which causes memory loss and causes Alzheimer's disease. Some scholars have found that about 20% of Alzheimer's patients are full foodies in their early adult years. Zhong Nanshan said. In addition, heavy intestinal load will lead to gastrointestinal diseases, easy to lead to "three high", leading to high blood pressure, fatty liver, diabetes and other "rich diseases", and even lead to osteoporosis.
" seven or eight full is the healthiest. To be healthy, three points of hunger and cold. He also recommends using grains instead of fine rice white noodles, reducing the consumption of red meat, and reducing the intake of high fructose syrup to reduce the risk of atherosclerosis and intestinal tumors.
" is the most typical seafood eating too much, rich in radon food can lead to higher uric acid, while foods containing high fat and oxidizing substances, it is easy to lead to hyperemia and coronary heart disease, food containing a large amount of saturated fat and cholesterol, such as fat and animal offal, is one of the important causes of heart disease, long-term large intake of such foods will significantly increase the risk of cardiovascular disease and malignant tumors (such as colon cancer, breast cancer). Li Kai told reporters that nutritional metabolism is now getting more and more attention from scientists, hoping that through scientific research, a balanced diet, reduce the risk of disease.
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