Male infertility and glutathione

It is a well-known fact that the number of sperm in men has halved on average over the past 50 years And the amount of semen in modern men is more than 20% less than that in their fathers' generation, which was published in the British Medical Journal Vol 305 in 1992 Data from a recent Aberdeen study showed that men's sperm concentration had declined by 29% over the past 14 years It is known that continuous organic pollutants and endocrine disrupting chemicals can cause reproductive system damage Exposure to alcohol, pesticides, food additives and other chemicals on sperm damage is one of the reasons for children's mental retardation and obstacles Risk lifestyles known to reduce sperm quality include smoking, alcohol consumption, long-term stress and malnutrition Other causes of male infertility include congenital factors, such as prostatitis, diabetes and other health conditions can also affect sperm secretion Pollution is theft for our future, and not many people can avoid it We have little to do with the persistent environmental toxins we face However, certain measures can be taken to minimize the impact of environmental pollution and toxins on the body For example, better lifestyles and nutrition can prevent and repair their damage to the body Some nutritional therapies and antioxidants have been shown to be beneficial to the treatment of male infertility and to the improvement of sperm quantity, sperm morphology and motility They include carnitine, arginine, zinc, selenium, vitamin B12, vitamin C, vitamin E, glutathione and coenzyme Q10, etc Studies have shown that supplementation with antioxidants, especially glutathione, can improve sperm quality and increase the chances of muscle conception Therefore, if you smoke, drink alcohol, have stress, chemicals, radiation, pesticides, or take drugs that affect fertility, such as salbutamol, salicylic acid, anabolic steroids and marijuana, you should consider adding antioxidants to reverse the damage Why are antioxidants important for improving sperm quality? Mammalian sperm is covered with a layer of polyunsaturated fatty acids These unsaturated fatty acids are easily damaged by free radicals or reactive oxygen species Lipid peroxidation damage sperm cell membrane, which is considered as the key mechanism of sperm damage induced by reactive oxygen species, and lead to loss of sperm viability, abnormal sperm morphology, decreased oocyte permeability and infertility In order to protect sperm from damage, the body relies on powerful antioxidative enzymes such as superoxide dismutase, catalase and glutathione peroxidase / reductase There are several antioxidant enzymes in seminal plasma and spermatozoa, including glutathione peroxidase, glutathione reductase, superoxide dismutase, etc Appropriate antioxidant enzyme activity can protect sperm from oxidative attack Glutathione peroxidase / reductase plays a key role in protecting human sperm from oxidative damage Why is glutathione important for sperm quality and fertility? The decrease of glutathione level will destroy the integrity of sperm membrane in the process of sperm production due to the increase of oxidative stress The decrease of glutathione level in sperm is one of the causes of male infertility There is clear clinical evidence that infertile men have high levels of oxidative stress, which may hinder their sperm quality Why does glutathione help to treat male infertility? The results show that glutathione treatment may be an effective treatment, especially in the case of infertility caused by reactive oxygen species or exposure to toxic substances.