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    Home > Biochemistry News > Biotechnology News > Mapping ProteinDNA and ProteinProtein Interactions of ATP-Dependent Chromatin Remodelers

    Mapping ProteinDNA and ProteinProtein Interactions of ATP-Dependent Chromatin Remodelers

    • Last Update: 2020-12-01
    • Source: Internet
    • Author: User
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    Chromatin plays a key regulatory role in several
    DNA
    -dependent processes as it regulates DNA access to different protein factors. Several multisubunit protein complexes interact, modify, or mobilize nucleo-somes: the basic unit of chromatin, from its original location in an ATP-dependent manner to facilitate processes, such as transcription, replication, repair, and recombination. Knowledge of the interactions of chromatin remodelers with nucleosomes is a crucial requirement to understand the mechanism of chromatin remodeling. Here, we describe several methods to analyze the interactions of multisubunit chromatin-remodeling enzymes with nucleosomes.
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