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In the fields of bioimaging and phototherapeutics, the structural adjustment of materials to control their optical properties is an important and common way to explore new materials and discover new applications
In this context, the authors, Chunyu Zhou et al.
Figure 1: Schematic diagram of the action of AuNCs@ SiO2
AuNCs@SiO 2 is not easily affected by other tissues due to its TME activation property, and exhibits excellent photoacoustic imaging performance (Fig.
Figure 2: Comparison of ultrasound and photoacoustic imaging of normal tissue and tumor tissue
Meanwhile, the photothermal conversion efficiency of AuNCs@SiO2 is as high as 82.
Figure 3: Comparison of conversion efficiencies of AuNCs@SiO 2 and other reported photothermal therapy agents: 1) AuNCs@SiO 2 ; 2) Au 3 Cu@PEG TPNCs; 3) Au-wires-on-AuNR; 4) Pt Spiral; 5) Cu 2 MnS 2NPs; 6) Nb 2 C (Mxene); 7) Cu 3 BiS 3NRs; 8) L-Pdots; 9) TBDOPV-DT NPs; 10) SPN-DT
Figure 4: Photothermal infrared thermal imaging of 4T1 tumor-bearing mice injected with PBS and AuNCs@SiO 2 (1064 nm NIR-II laser, 0.
Figure 5: Variation trend of tumor site temperature and irradiation time after injection of PBS and AuNCs@SiO 2
Figure 6: Comparison of tumor size in mice after receiving corresponding treatments (I: PBS; II: AuNCs@SiO 2 ; III: PBS+Laser; IV: AuNCs@SiO 2 +Laser)
Summary: For the first time, the authors successfully synthesized TME-responsive silica-wrapped self-assembled gold nanochains with both photoacoustic imaging and photothermal therapy functions
American PhotoSound Small Animal 3D Photoacoustic/Fluorescence Imaging System (PAFT)
The American PhotoSound Small Animal Whole Body 3D Photoacoustic/Fluorescence Imaging System (PAFT) provides a complete solution for in vivo imaging and characterization of small animals
It can realize near-infrared region one and near-infrared region two (670-2600 nm) mouse whole body 3D photoacoustic/fluorescence imaging system, using OPO tunable laser, providing 670-2600 nm continuous pulse laser, complete 3D photoacoustic imaging (with Full 3D imaging with 100 um isotropic resolution, non-slice stack imaging), high throughput (256 electron channels), high sensitivity (60 nM ICG), desktop design, easy to use, fast imaging (complete one 3D scan) 30 seconds)
● American PhotoSound Small Animal Whole Body 3D Photoacoustic/Fluorescence Imaging System
● Mouse Anatomy Application Notes - American PhotoSound Small Animal Whole Body 3D Photoacoustic/Fluorescence Imaging System
● Photoacoustic Imaging Applications | Exploring Atherosclerotic Plaques
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