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Proteins are vital to the function of our cells, but many questions about their synthesis, quantity, function, and defects remain unanswered
Two Methods of Analyzing Proteins by Mass Spectrometry
Shotgun proteomics mainly uses two methods: Data Dependent Acquisition (DDA) and Data Independent Acquisition (DIA)
As a result, this method generates a large amount of data, and the complexity of the information obtained is greatly increased
Combine DDA and DIA
Jürgen Cox and his team have now developed a software that provides a complete calculation workflow for DIA data
In addition, the software supports new technologies such as bootstrap DIA, BoxCar DIA and trapped ion mobility spectroscopy DIA
Enable researchers to perform complex proteomics data analysis
MaxDIA is a free software that can be used by scientists all over the world
Sinitcyn said that its goal is to "apply the mass spectrometry technology of the Max Planck Institute of Biochemistry to the clinic
Journal Reference :
Pavel Sinitcyn, Hamid Hamzeiy, Favio Salinas Soto, Daniel Itzhak, Frank McCarthy, Christoph Wichmann, Martin Steger, Uli Ohmayer, Ute Distler, Stephanie Kaspar-Schoenefeld, Nikita Prianichnikov, Şule Yılmaz, Jan Daniel Rudolph, Stefan Tenezer , Nagarjuna Nagaraj, Sean J.