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    Home > Biochemistry News > Biotechnology News > Measurement of [3H]PN200-110 and [125I]-Conotoxin MVIIA Binding

    Measurement of [3H]PN200-110 and [125I]-Conotoxin MVIIA Binding

    • Last Update: 2021-02-27
    • Source: Internet
    • Author: User
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    Intracellular Ca
    2+
    ([Ca
    2+
    ]
    i
    ) can rise primarily via release from intracellular storage sites (e.g., the endoplasmic reticulum) or via entry across the membrane down the steep concentration gradient (
    1

    3
    ). Ca
    2+
    can enter through two main classes of plasma membrane-located Ca
    2+
    channels: receptor operated and voltage sensitive (
    4

    7
    ). Voltage-sensitive Ca
    2+
    channels are involved in a wide and diverse array of physiological responses including neurotransmitter release (
    8
    ). In addition, many guanine nucleotide protein (G) coupled receptors couple to voltage-sensitive Ca
    2+
    channels to reduce Ca
    2+
    influx (
    9
    ,
    10
    ).
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