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Measurement of Sphingomyelin and Ceramide Cellular Levels After Sphingomyelinase-Mediated Sphingomyelin Hydrolysis

 Last Update: 2020-11-23
 Source: Internet
 Author: User

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phospholipids

2 4 pentanedione

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Sphingomyelin (SM) is the latest addition to the family of membrane phospholipids that is a source of molecules behaving asintracellular messengers (
1
). Ceramide is one of the products of sphingomyelin hydrolysis by specific sphingomyelinases (SMases) and appears to be involvedin the signaling of apoptosis initiated by regulatory molecules that include cytokines, interferon-γ (IFN-γ), and chemotherapydrugs, as well as UV and ionizing radiations (
2
–
4
).

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