Mechanism of GLS1 aggregation into rod-like structures to promote glutamine starvation-induced apoptosis

On April 4, 2022, the research group of Prof.

Glutamine is a very important energy substance and an important provider of carbon and nitrogen sources in biosynthesis.

Researchers from Qinxi Li's group found that knockout of GLS1 in multiple cell lines significantly inhibited apoptosis induced by glutamine starvation

Figure 1.

Further studies revealed that glutamate is a negative regulator of intracellular GLS1 formation of rod-like structures

Figure 2.

Large amounts of GLS1 are present in rod-like structures at the core of clinical gastric and pancreatic cancer samples

Figure 3.

In conclusion, this study revealed the molecular mechanism of GLS1's structural remodeling by sensing the concentration of its products, thereby initiating apoptosis (Fig.

Figure 4.

Professor Li Qinxi is the corresponding author of the paper, Assistant Professor Jiang Bin, Assistant Professor Zhang Jia and Ph.

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(Photo/Wen Li Qinxi's research group)