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Compared with the general population, people with severe mental illness, including schizophrenia, have higher cardiovascular mortality, and the association has become stronger over the decades, according to an April 19 issue in PLOS ONE.
Previous studies have identified higher cardiovascular morbidity and mortality in people with severe mental illness, but it is unclear whether this association changes over time
Overall, cardiovascular-related mortality was approximately twice as high in patients with severe mental illness as in the general population (SMR 1.
It was not possible to explore all possible confounders, such as smoking and obesity, and there was also considerable heterogeneity among the studies included in the meta-analysis
"The increased relative risk of cardiovascular disease diagnoses in recent decades may be the result of differences in the prevalence of smoking or increased use of antipsychotics between patients with severe mental illness and the general population
Lambert added: "Our systematic review and meta-analysis of more than 100 studies confirmed a strong link between severe mental illness and cardiovascular disease that changed in the 1990s and early 2000s.
