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12.
1.
2 Metabolism and Toxicology
12.
1.
2.
1 Metabolic processes in the body
TC is easily absorbed by oral administration, but not completely
.
The speed and extent of oral absorption can vary depending on the animal species and the amount of gastrointestinal content
TCs are mainly distributed in extracellular fluid and can enter the abdominal cavity, thoracic cavity, fetal circulation and milk, but do not enter the cerebrospinal fluid through the blood-brain barrier
.
The concentration of TCs in milk can reach 50% to 60% of the concentration in plasma, and the concentration in the milk of animals suffering from mastitis is higher.
The kidney is the main excretory organ of TCs
.
When repeated administration, the general clinical dose, the drug discharged in the original form in the urine can reach the required concentration in the urine to inhibit the growth of sensitive bacteria
12.
1.
2.
2 Toxicology and adverse reactions
TCs accumulate in liver tissues, causing liver damage, and can also cause allergic reactions, double infections, and teratogenic effects
.
Long-term intake of food with excessive TCs residues can inhibit the phagocytic ability of white blood cells.
Due to the similar chemical structure of these drugs, bacteria are prone to drug resistance, so they are also prone to cross drug resistance
.
The reason for the development of drug resistance may be that the permeability of the bacteria to this class of antibiotics has decreased, resulting in the low concentration of the drug in the bacteria and the failure of antibacterial effect
