Metabolism: Decreased pulmonary surfactants DMPC and PMPC enable SARS-CoV-2 infection in obese patients.

Background: The ongoing COVID-19 outbreak caused by the novel coronavirus infection has killed more than 6 million people worldwide

Background: The ongoing COVID-19 outbreak caused by the novel coronavirus infection has killed more than 6 million people worldwide

COVID-19 is primarily a respiratory disease through which the virus initially enters

Since obesity is characterized by abnormal lipid metabolism, we reasoned that alterations in the lipid composition of pulmonary surfactant might impair its defense against 2019-nCoV infection

Objective: We hypothesized that changes in the lipid composition of pulmonary surfactant in obese patients may promote 2019-nCoV infection and lead to severe 2019-nCoV disease

Methods: Lung tissue and bronchoalveolar lavage fluid (BALF) were subjected to lipidomic analysis using LC-MS/MS

RESULTS: Lipidomics analysis revealed that myristic acid-containing dimyristoyl-PC (DMPC) and palmitoylmyristoyl-PC (PMPC) were reduced in lung tissue and BALF of high-fat diet-induced obese mice

Figure 1 In 293T/ACE2 and Vero E6 cells (n = 6), BALF lipids (25 μg/ml) from diet-induced obese mice enhanced pseudotyped novel compared to lipids from lean control mice coronavirus infection

Figure 1 In 293T/ACE2 and Vero E6 cells (n = 6), BALF lipids (25 μg/ml) from diet-induced obese mice enhanced pseudotyped novel compared to lipids from lean control mice coronavirus infection

Figure 2 A–B.

Figure 2 A–B.

Conclusion: The reduction of DMPC and PMPC in pulmonary surfactant may promote novel coronavirus infection

Original source: Du K, Sun L, Luo Z, et al.
Reduced DMPC and PMPC in lung surfactant promote SARS-CoV-2 infection in obesity .
Metabolism 2022 Mar 18;131 Reduced DMPC and PMPC in lung surfactant promote SARS-CoV- 2 infection in obesity

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