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About 2 billion natural killer cells circulate in our body and play an important role in the body's defense against cancer and infection
.
This led researchers to believe that natural killer cells could be used in immunotherapy to treat the same diseases
“By taking cells from adult tissues – such as hair follicles or skin cells – we can reprogram them to be in an embryonic state – so-called iPS cells, or induced pluripotent stem cells
.
Because of their embryonic state, These cells can then develop into different types of cells of the body, including blood cells," says nielsbjarne Woods, associate professor at Lund University and corresponding author of the study
In the "induced pluripotent stem cell (iPS) hematopoietic system," the research team discovered a "metabolic switch" that activates the production of specific types of blood cells, thereby increasing the production of natural killer cells
.
"In our cells, there are mitochondria that act like power plants, and chemical reactions provide energy
to the cells.
By feeding the cells different substances, we can influence the production of energy and influence which types of blood cells are grown
The increase in mitochondrial activity led to a substantial increase in the levels of natural killer cells
.
This suggests that metabolism is an important regulator of embryonic blood development
"Using metabolic factors, we determined how to control the production of specific blood cells from iPS cells
.
We plan to modify natural killer cells to target and destroy specific cancers
Journal Reference :
Leal Oburoglu, Els Mansell, Isaac Canals, Valgardur Sigurdsson, Carolina Guibentif, Shamit Soneji, Niels‐Bjarne Woods.
