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    Home > Biochemistry News > Biotechnology News > Metabolism of high-density lipoprotein (HDL).

    Metabolism of high-density lipoprotein (HDL).

    • Last Update: 2020-10-27
    • Source: Internet
    • Author: User
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    the nameHDL is produced in the liver and small intestine. HDL contains a lot of lipoproteins, including apoA, apoC, apoD and apoE, and the lipids are mainly phospholipids.. After HDL is secreted into the blood, the new HDL is HDL3, on the one hand, it can be used as a lipoprotein supply to transfer apoC and apoE to the new CM and VLDL, and at the same time in the process of CM and VLDL metabolism, the lipoprotein is transported back to HDL, and constantly with CM and VLDL lipoprotein transformation. HDL, on the other hand, can ingest free cholesterol released by extra-hepatic cells in the blood and is catalyzed by lecithin cholesterol esteryl
    transferase
    (LCAT) to produce cholesterol esters.
    this enzyme is synthesized in the liver, secreted into the blood and active, can be activated by apoAI in HDL, the resulting cholesterol esters can be transferred to VLDL. Through the above process, HDL density reduction is converted to HDL2. HDL2 is eventually degraded by liver ingestion.Thus, the main function of HDL is to transfer cholesterol released by extra-hepatic cells to the liver, which prevents cholesterol build-up in the blood, prevents atherosclerosis, and the concentration of HDL2 in the blood is negatively related to coronary atherosclerosis.
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