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    Home > Biochemistry News > Biotechnology News > Metabolism of low-density lipoprotein (LDL).

    Metabolism of low-density lipoprotein (LDL).

    • Last Update: 2020-10-26
    • Source: Internet
    • Author: User
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    . The ingestion and degradation


    5-6 cells of the LDL LDL is transformed by VLDL, the main lipids in the LDL are cholesterol and esters, and the lipoprotein is apoB100.. LDL can be identified in the blood by the apoB100 subject present on the surface of
    tissues
    cells outside the liver, through which it is mediated, swallowed into the cell, fused with lysosomes, and cholesterol esters hydrolyzed into cholesterol and fatty acids. In addition to participating in the production of cellular biofilms, this cholesterol also has an important regulatory effect on the metabolism of cholesterol in cells
    : (1) reduces the synthesis of cholesterol in cells by inhibiting HMG Coa reductase
    activity; (acyl CoA:cholesterol acyltransferase, ACAT) makes cholesterol-producing cholesterol esters stored; (3) inhibits transcription of LDL receptor protein
    gene
    , reduces the synthesis of LDL receptor protein, and reduces cell intake of LDL (Figure 5-6).In addition to the above-mentioned subject-mediated LDL metabolic pathway, the engulfing cells of the endostropheric mesh system in the body can also ingest LDL (mostly chemically modified LDL), and the cholesterol produced by this pathway does not have the above regulatory effect. Therefore, excessive intake of LDL can lead to the emptying of phagocytosphage.above, the function of LDL metabolism is to transport endogen cholesterol synthesized by the liver to the extra-liver tissue, ensuring the need for cholesterol in tissue cells.


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