Metabolism: Relationship between weight gain, body shape changes, and the risk of non-alcoholic fatty liver disease in early adulthood.

Obesity was identified as a major risk factor for the development of non-alcoholic fatty liver disease (NAFLD).
, the effects of changes in obesity dynamics over the course of life on NAFLD risk remain unclear.
, researchers collected data on 11,054 women who participated in the Nurses' Health Study II cohort in a study published in Metabolic Diseases, an authoritative journal of metabolic diseases.
determined early adult weight at age 18 and weight gain in early adulthood every 2 years.
researchers used group-based modeling to identify five body shape trajectories between the ages of 5 and 50.
NAFLD is confirmed by a doctor for fatty liver disease and uses proven methods to exclude excessive alcohol intake and viral hepatitis patients.
20 years of follow-up, researchers recorded 3,798 cases of NAFLD.
compared to women with stable body weight (±2kg), women who gained ≥20kg had a multivariable aHR of 6.96 (95% CI of 5.27-1.18) and were still significant after further adjustments to their early-adult BMI and BMI updates (P trend was 0.0001).
compared to women with moderate stable body shape trajectory, NAFLD's multivariate aHR was 2.84 (95% CI 2.50-3.22) among subjects with weight gain and moderately increased subjects 2.60 (95% CI is 2.27-2.98) and 3.39 (95% CI is 2.95-3.89) among moderately significantly increased subjects.
result, weight gain in early adulthood and body shape change trajectories were significantly and independently associated with the risk of NAFLD occurring in middle age.
maintaining a slim and stable weight may provide the greatest benefit in preventing NAFLD.
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