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Circulating branch chain amino acids (BCAA) are associated with heart metabolic risk, although the mechanisms that cause their accumulation are not yet clear.
, researchers aim to assess the relationship between fasting, metabolic syndrome and type 2 diabetes (T2D) and circulating BCAA levels in a study published in Metabolic Diseases, an authoritative journal in the field of metabolic diseases, in the hope of gaining new insights into metabolism.
researchers cross-sectional analysis of 25,740 female health study participants (with an average age of 55).
in the multivariate linear regression model, in women without metabolic syndrome or T2D (average difference percentage is -5.1%; 95% CI -5.8 to -4.5) and In women with only metabolic syndrome (-3.7%; -4.9, -2.6), fasting was associated with lower plasma BCAA, interacting p-0.002 compared to non-fasting states.
, however, there was no difference in BCAA status in T2D women (0.4%; -3.7 to 4.7).
researchers observed that higher BCAA was associated with deteriorating metabolic health.
, with the exception of women with T2D, an empty stomach was associated with lower plasma BCAA.
these results support the assumption that damaged BCAA decomposing metabolism may be a feature of T2D pathophysiological changes.
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