Metformin hydrochloride tablets orange peel book information

This orange peel book database is jointly produced by yaozhi.com and tonghuayi.com Drug name metformin hydrochloride tablet type specification 0.25g/0.5g the active ingredient of Bristol Myers Squibb the active ingredient of metformin hydrochloride Metformin can not only reduce blood sugar, but also reduce weight and hyperinsulinemia in patients with type II diabetes mellitus, especially those with obesity and hyperinsulinemia As a first-line drug for the treatment of type II diabetes, metformin is often used in combination with other oral hypoglycemic drugs, and in principle, it should always be kept in the medication list The molecular target is: 5 '- amp activated protein kinase subunit beta-1 The application of metformin is full of twists and turns As early as 1929, slotta and tschesche reported that metformin had hypoglycemic effect on rabbits, and later the research results were ignored In the early 1950s, Eusebio y Garcia, a doctor in the Philippines, and Janusz supniewski, a pharmacologist in Poland, ignored the hypoglycemic effect of metformin when they studied its many active categories Metformin was included in the UK formulary in 1958, but until the 1970s, with the withdrawal of other metformin drugs, metformin became more and more concerned: it was listed in Canada in 1972 and in the United States in 1994 The original manufacturer of this product is Bristol Myers Squibb In 1998, FDA determined 1g tablet positioning reference preparation; Japan PMDA took 250mg tablet of Dainippon Sumitomo company as reference; in the European Union, there is only compound preparation, while in many member countries, there is single preparation In 1992, 0.25g tablet of Shaanxi Ankang Jiren pharmaceutical was first listed in China At present, the domestic production approval of this product includes 0.25g and 0.5g two specifications According to the selection principles of national reference preparations, the reference preparations of Bristol Myers Squibb and Dainippon Sumitomo are recommended BCS classification (who) drug name BCS classification specification document metformin hydrochloride 3 500mg BCS classification (2005) issued by the World Health Organization PDF domestic import situation import product category import reference situation includes non-original research drug, non-U.S and Japan reference recommended reference drug name, trade name, reference holding company, reference listing country details Glucphage Bristol Myers Squibb metformin hydrochloride tablets melbin tab 250mg Dainippon Sumitomo Pharma Co, Ltd (Sumitomo) Japan (specification: 250mg) check domestic approval document (check more) (118) drug name approval document No specification manufacturer approval time metformin hydrochloride tablet Guoyao Zhun Zi h35020664 0.25g Meiji Pharmaceutical (Xiamen) Co., Ltd 2015-01-20 dimethylbiguanide hydrochloride tablet Guoyao Zhun Zi h34022410 0.25g Wuhu Boying Pharmaceutical Technology Co., Ltd 2015-10-30 gjzz of metformin hydrochloride tablets h44020837 0.25g Lizhu pharmaceutical factory of Lizhu group 2015-06-18 gjzz of metformin hydrochloride tablets h44023395 0.25g Guangdong Xiangxue Pharmaceutical Co., Ltd 2015-02-17 gjzz of metformin hydrochloride tablets h520296 0.25g Guizhou shengjitang Pharmaceutical Co., Ltd 2015-03-17 gjzz of metformin hydrochloride tablets h4102643 0.25g Shanghai shourusong pharmaceutical Biyang Pharmaceutical Co., Ltd 2015-07-17 GMZ h41024137 0.25g Henan Xingyuan Pharmaceutical Co., Ltd 2015-05-21 GMZ h41020541 0.25g Baiyunshan Tangyin Dongtai Pharmaceutical Co., Ltd 2015-03-03 GMZ h4102069 0.25g Zhengzhou Ruikang Pharmaceutical Co., Ltd 2015-03-06 extended information reference filing information (42) U.S dissolution information (1) U.S listing information (281) EU listing information (15) drug registration information (84) drug bid winning information (1720) Chinese drug standard (9) foreign standard information (59) drug product description information (14) Note: this orange peel book database is jointly produced by yaozhi.com and freehand Data source: Orange Book Database