MIB index predicts the value of the recurrence of the diffuse vestibular neuroblastoma

The literature reports that the MIB-1 marker index (LI) plays an important role in the recurrence of pretrial neurosymaPretrial neuroblastomas, which express the apoptosis factor Bax, showed a higher proliferation index through the MIB-1 marker indexSimilarly, pretrial neuroblastomas with type 2 neurofibromatosis have a higher MIB-1 index than those of a perbilistic vestibular neuroblastoma, regardless of age- Excerpted from the article(Ref: Panigrahi M, et alWorld Neurosurg2018 Dec;120:e1203-e1207doi: 10.1016/j.wneu.2018.09.039Epub 2018 Sep 18vestibular schwanommas, VS) or hearing neuromas are benign tumors originating from the cells of the neurosis Chevan's, mainly from the nerves in the vestibularIts long-term prognosis was good, but the recurrence rate was between 0.5% and 9.2%It is important to determine the predictors of relapse in patients, and the documented MIB-1 marker index (LI) plays an important role in the recurrence of pretrial neurosaromasPretrial neuroblastomas, which express the apoptosis factor Bax, showed a higher proliferation index through the MIB-1 marker indexSimilarly, pretrial neuroblastomas with type 2 neurofibromatosis have a higher MIB-1 index than those of a perbilistic vestibular neuroblastoma, regardless of ageAt present, there is less literature on the factors regulating apoptosis and cell proliferation in vestibular neuroblastomaManas Panigrahi of the Institute of Neurosurgery at the TrenganaKrishna Institute of Medical Sciences, India, and others assessed the role of MIB in relapse after the release of pretrial neuroblastoma surgery, the results of which were published in the December 2018 issue of the journal World Neurosurgerythe retrospective cohort study included 144 patients with diffuse pretrial neuroblastoma who underwent surgical removal at a tertiary medical center between January 2010 and July 2015 The criteria selected include: the excision of the vestibular neuroblastoma after celiac, and the foretrial neuroblastoma confirmed by histopathology according to who-2007 classification of central nervous system tumors Except for patients with patients with unable to follow up and neurofibromatosis An MRI test is performed 3 months, 12 months, 24 months after surgery or when the condition needs to be assessed Tumor recurrence refers to the increase of more than 5mm in the maximum diameter of the tumor residue in the last MRI follow-up The relationship between MIB index and recurrence after vestibular neuroblastoma was studied and analyzed Of the 144 patients , 77 (53.5%) were male; the average age was 43.95 to 12.86 years; and the maximum diameter of the foretrial neuroblastoma was 40.25 to 7.23 mm In 77 patients (53.5%) the tumor was on the left and 66 (45.8%) on the right 1 case was a double-sided vestibular neuroblastoma with a larger right side The duration of symptoms was 0.2-48 months, with an average of 11.3 to 11.8 months Fifty-two (36.1%) tumors were completely excisioned, 81 cases (56.3%) were nearly completely excisioned, and the remaining 11 cases (7.6%) were fully excisioned Postoperative follow-up time was 24-60 months, with an average of 37.99 to 10.09 months in 18 patients (12.5%) of patients, a recurrence of the vestibular neuroblastoma was found The difference between the largest diameter of the tumor before surgery in the tumor recurrence group and the unrecurrent group was not statistically significant (42.22 to 8.04mm compared to 39.64 to 7.00mm; P.191) The average MIB index in patients in the tumor recurrence group was significantly higher than that of the non-recurrence group (4.78 to 5.77mm compared to 1.89 to 1.48 mm; P 0.001) There was no statistical difference between the two groups in terms of excision range and postoperative complications The MIB index is the only important factor in predicting recurrence (beta-1.355; 95% CI, 1.07-1.78; P-0.031) On the subject's operational characteristic curve, the truncated value of MIB was 3.5% and the specificity was 84.1% authors point out that the MIB index of 3.5% at the time of the first symptoms of the foretrial neuroblastoma indicates that the tumor is likely to recur In contrast, the maximum size of the tumor and the degree of tumor removal were not related to the recurrence of anterior neuroblastoma Predicting proliferation through The MIB Index is helpful to properly manage patients with diffuse vestibular neuroblastoma.