Microbial catalyzed ceramic material promotes bone tissue regeneration

Science and Technology Daily News (Reporter Wang Chun) The reporter learned from the Shanghai Institute of Ceramics, Chinese Academy of Sciences on November 22 that the Wu Chengtie research team of the institute proposed the idea of ​​microbial catalytically active minerals to induce osteogenesis, and used microbial catalysis to construct a Surface micro-nano structures of bioceramic scaffolds for bone tissue regeneration

Inspired by the phenomenon of microbial mineralization in nature, Wu Chengtie's team grows bioactive nano calcium carbonate minerals on the surface of traditional ceramic materials (silicates) through microbial catalysis, and combines traditional ceramic materials with microbial-based active materials for Bone tissue regeneration

Bone is a complex biomineralized tissue composed of organic (cells, proteins) and inorganic (hydroxyapatite, calcium carbonate) substances at the micro and nanoscale

More and more studies have shown that the micro-nano topography and chemical characteristics on the surface of biomaterials can effectively regulate the osteogenic activity of cells

The research team used the metabolism of urease-producing bacteria to induce a uniform biomineralized layer on the surface of the ceramic material

In addition to being used for bone tissue regeneration, this strategy of combining microorganisms with tissue engineering also provides new ideas for the preparation of biomedical materials