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Syphilis is a multi-stage transmission of the treponemal subspecies pallidum (TP) caused by treponemal syphilis
Sexual transmission usually occurs during the first year of infection during the primary, secondary and early incubation periods
Bacterial typing is usually most successful on cultured strains, from which a large amount of specific bacterial DNA
The aim of this study was to investigate possible intra-patient TP strain variants and assess possible associations with specific body locations
The study included 162 male patients with syphilis who visited the Amsterdam Centre for Sexual Health between 2018 and 2019 and had TP DNA
The Venn diagram shows the number of patients with TP DNA detected by anatomical location and the number of patients who obtained peripheral blood (B) of type TP in 93 patients with at least one type of typing sample
An overview of 162 patients enrolled in the SHC in Amsterdam, the Netherlands, between 2018 and 2019, patients with two or more acquired TP-MLST types in different anatomical locations (n = 12).
Can be obtained from at least one anatomical site or from a peripheral blood typing sample (119/287) from 93/162 (57%) patients, including: 48 cases (52%) primary syphilis, 35 cases (38%) secondary syphilis, and 10 cases (11%) early incubation syphilis
There was no difference in the distribution of TP-MLST typing in patients with different syphilis stages
Source: Zondag HCA, Nieuwenburg SA, Himschoot M, PallidumTreponema pallidum Subspecies Intrapatient Homogeneity at Various Body Locations in Men with Infectious Syphilis.