Microbiome: A synthetic probiotic can treat colorectal cancer

Successful chemoprevention or chemotherapy is achieved by targeted delivery of preventive drugs or therapeutic agents to malignant tumors at the initial stage of canceration

Cancer is the main cause of human death, and the global burden is rising

Bacteria can be used to treat cancer, and their recognition as anticancer agents can be traced back more than a century ago

Colorectal cancer (CRC) is a serious cancer that causes nearly 900,000 deaths each year

The schematic diagram depicts the expected mode of action of the synthetic probiotic PP*-P8 with the ALR complementary system

Image source: https://doi.

In this study, the authors used P8 to develop an advanced anti-colorectal cancer probiotic, and through two different mouse models: DLD-1 xenograft and azomethane (AOM) and dextran sodium sulfate (DSS) induced colitis-related tumor formation, proving its powerful curative effect

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Reference

Chung et al.

Microbiota.