Microbiome: Fecal microbiome transplantation maintains the relief of Crohn's disease

Previous studies have shown that the use of fecal microbiome transplantation (FMT) intestinal microbiome can effectively treat Crohn's disease (CD).
, however, there are no randomized controlled clinical trial results, and this randomized, single-blind, false-controlled trial was designed to FMT in adults with colon or rectal CD, the results of which were published online in Microbiome.
selected patients received oral corticosteroids at the onset of the disease.
once the patient enters clinical remission, the patient receives FMT or a false transplant at random during colonoscopy.
gradually reduce corticosteroids and have a second colonoscopy in week 6.
end point of the disease is the implantation of the available microbiome in week 6 (Sorensen Index , 0.6).
results showed that eight patients received FMT and nine received fake transplants.
patients reached the main endpoint.
steroid-free clinical remission rates were 44.4% (4/9) and 33.3% (3/9) respectively in the steroid-free transplant group at 10 and 24 weeks, respectively, and 87.5% (7/8) and 50.0% (4/8) in the FMT group (4/8;
of Crohn's disease endoscopic severity decreased within 6 weeks of FMT (P s 0.03), but there was no decrease in the fake transplant group (P s 0.8).
, the CRP level increased after 6 weeks of false porting (p s 0.008), but the FMT group did not increase (p s 0.5).
no transplantation of the supply microbiome was found to be associated with seizures.
no adverse events were found.
, the results show that no patient has reached the primary endpoint.
in this pilot study, the higher implantation of the supply microbiome was associated with the maintenance of mitigation.
these results will be confirmed in a larger study (NCT02097797).
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