Microcapsules of tilmicosin and its preparation

The technology discloses a enteric tilmicosin sustained-release microcapsule and a preparation method thereof, belonging to the field of tilmicosin preparation The enteric coated timmicosin sustained-release microcapsule is made of 10-50wt% timmicosin powder, 40-88wt% fat powder auxiliary material and 2-10wt% enteric coated material The enteric coated material is one or more of cellulose acetate, hydroxypropylmethylcellulose phthalate, acrylic resin L, acrylic resin s, polyvinyl acetate, hydroxypropylmethylcellulose acetate succinate The prepared microcapsule has a diameter of 50? 200 μ M the preparation method includes coating the original powder and auxiliary materials of tilmicosin * times, coating the second time with enteric coated materials, and drying to obtain the finished product The invention achieves the purpose of slow release, prolongs the action time of timicosin, improves the fluidity and dispersion of the medicine, significantly improves the efficacy and reduces the amount of medicine added The technology belongs to the field of tilmicosin preparation, in particular to an enteric tilmicosin sustained-release microcapsule and a preparation method thereof Tilmicosin is a kind of broad-spectrum antibiotic for livestock and poultry It is mainly used to prevent and control animal pneumonia, Mycoplasma disease and mastitis of lactating animals It has been widely used in livestock production At present, the dosage forms included in the national standard include premix, soluble powder, solution and injection Tilmicosin has a very bitter taste and poor palatability, which is irritant to gastric mucosa and affects the intake of animal body At the same time, the general tilmicosin premixes and powders have poor fluidity, low dispersion and are not easy to mix when mixed At present, there are mainly the following types of temicaosin preparations in China: 1 Ordinary powder: directly mix temicaosin with excipients in proportion, the process is extremely simple, but it is difficult to mix them evenly because of the large difference between temicaosin and feed particles In addition, it has extremely bitter taste, poor palatability, instability in the stomach, easy degradation and irritation to the gastric mucosa 2 Ordinary granules: the original powder and auxiliary materials of tilmicosin are simply mixed to make granules with appropriate particle size, so as to improve the mixing effect of tilmicosin preparation and feed However, like ordinary powder, it tastes extremely bitter, which affects animal feeding, dissolves completely in gastric acid, has no sustained-release function and poor antibacterial and growth promoting effect In view of this, the purpose of this technology is to propose a enteric coated timicosin sustained-release microcapsule according to the biological characteristics of timicosin, so as to improve the palatability of timicosin, completely cover up the strong bitter taste, not affect the intake of pigs, and improve the fluidity and dispersion of the drug, significantly improve the efficacy and reduce the amount of drug added The other purpose of the technology is to provide a preparation method of enteric coated ticarcin sustained-release microcapsules, which is simple and easy to prepare with low production cost In order to solve the above technical problems, the technical solution adopted in the technology is: a enteric coated ticarcin sustained-release microcapsule, which is made of 10-50wt% ticarcin original powder, 40-88wt% fat powder auxiliary material and 2-10wt% enteric coating material; the enteric coating material is cellulose acetate (CAP), hydroxypropylmethylcellulose phthalate.. [technical protection point] The enteric coated timicosin sustained-release microcapsule is characterized in that it is made of 10-50wt% timicosin powder, 40-88wt% fat powder auxiliary material and 2-10wt% enteric coated material; the enteric coated material is cellulose acetate, hydroxypropylmethylcellulose phthalate, acrylic resin L, acrylic resin s, polyvinyl acetate, hydroxypropylmethylcellulose acetate succinate One or more of peroxyesters; the diameter of the microcapsule is 50? 200 μ M [summary of technical features] 1 A enteric coated ticarcin sustained-release microcapsule, which is characterized in that it is made of 10-50wt% ticarcin powder, 40-88wt% fat powder auxiliary material and 2-10wt% enteric coated material; the enteric coated material is cellulose acetate, hydroxypropylmethylcellulose phthalate, acrylic resin L, acrylic resin s, polyvinyl acetate, hydroxypropylmethylcellulose acetate One or more succinates; the diameter of microcapsules is 50-200 μ M 2 The enteric tilmicosin sustained-release microcapsule according to claim 1, which is characterized in that the fat powder is made of soybean oil, fish oil, lecithin, expanded corn, vitamin E and antioxidant 3 The enteric tilmicosin sustained-release microcapsule according to claim 2, which is characterized in that the fat powder is composed of 20-40wt% soybean oil, 20-40wt% fish oil, 20-40wt% lecithin, 10-20w