MicroRNA regulates the biological processes of eye stem cells.

The microRNA-103/107 family (miRs-103/107) plays an important role in regulating the biology of stem cells in the epithelat cells at the edge of the cornea, Physicists.
study, published today in the Journal of Cell Biology, is the first to link autophagy and macrocytosphagy, two important cellular processes.
cell autophagy is the circulatory process by which cells degrade non-essential components in response to survival stress to provide nutrients and energy.
cell drinking process ingests fluids, cell membranes, bacteria and viruses from outside the cell and wraps them in small vesicles. Lead author of the
paper and professor of dermatology at Northwestern University School of Medicine, Robert LaWalk, said: "Our study confirms that miR-103/107 regulates both important processes simultaneously, ensuring that the autophagy process persists into the final stages of cell division and preventing the over-intake of fluid from extracellular cells by the macrocytosis process."
" researchers silenced miR103/107 and found that the large empty bubbles formed by giant drinks did not degrade from the epithellal cells at the edge of the cornea as usual, but were largely preserved.
to find out why, they used ultra-high-resolution structural light microscopes (SIM) to study the shape of large empty bubbles and found that the surface markers of empty bubbles were associated with autophagy.
further tests have shown that autophagy failed to hold on to the end due to a lack of miR103/107, resulting in large empty bubbles "sticking" to the cells.
LaWalk said the study is the first to uncover the mechanisms behind important biological processes in the corneal epithelial cells of the eye, and will lay the groundwork for studying the relationship between autophagy and macrocytosis in other cells.
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