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Migration of influenza virus nucleoproteins to the nucleolus is critical for the formation of ribonucleoprotein complexes

 Last Update: 2022-01-25
 Source: Internet
 Author: User

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The influenza A virus duplex ribonucleoprotein complex (RNP) is responsible for the transcription and replication of viral genomic RNA (vRNA) and plays a crucial role in the viral life cycle
.

RNP formation occurs within the nucleus of virus-infected cells, and the nuclear domains involved in this process remain unclear
.
A study published in ASM Journal by researchers from Japan shows that the nucleolus is an important site for the formation of functional RNPs
.

The researchers used several microscopy techniques to reveal that the main component of the viral ribonucleoprotein complex, the viral nucleoprotein (NP), temporarily resides in the nucleolus, the site of ribosomal RNA/protein assembly, where it forms Depends on nucleolar localization signals

Single-stranded negative-sense RNA virus

Therefore, the transcription, replication and RNP formation of influenza A virus are heavily dependent on the nuclear machinery of the host

Effects of nucleolar disruption on the formation of functional RNPs
.

Further experimental analysis demonstrated that the formation of functional double-helical RNPs of influenza A virus depends on the nucleolar migration of NPs
.

The findings underscore the importance of the nucleolus in the influenza virus life cycle

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