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On March 19, the team of Academician Wang Chen, Dean of the Chinese Academy of Medical Sciences and Peking Union Medical College, published an online titled "New Coronary Seroepidemiology and Persistence of Humoral Immunity: Based on the Wuhan Population" in the international top medical journal "The Lancet" The follow-up study" article.
After the study was unblocked in Wuhan, a rigorous multi-stage cluster random sampling method was used to test representative samples of nearly 10,000 Wuhan residents for new coronavirus antibodies, revealing the dynamic changes of serum antibodies in patients with new coronavirus.
Academician Wang Chen’s team published a study in the “Lancet” that the positive rate of COVID-19 antibodies in the Wuhan population was 6.
9%.
The study showed that among 9542 subjects, 532 were positive for antibodies to the new coronavirus and the population’s antibody positive rate was 6.
9%.
Academician Wang Chen, the lead author of the article, said that there is a big difference between the number of confirmed cases of new crowns in countries and regions around the world and the number of infections estimated based on the seropositive rate of the population.
The new crown seroepidemiology papers published in many countries around the world show that the ratio of the two ranges from several times to dozens of times, and more than 10 times.
For example, Los Angeles is 43.
5 times, the Netherlands is 30 times, and this study is 12.
4 times.
The main reasons include that most of the infected people are asymptomatic and mildly ill, plus the psychology and behavior of the infected people, the local virus nucleic acid detection capacity at the time of the epidemic, nucleic acid screening strategies, nucleic acid sampling methods, laboratory testing methods, etc.
As a result, the positive rate of antibodies is much higher than the incidence rate reported locally, and the number of infections calculated based on the positive rate of seroantibodies is also much higher than the number of diagnosed cases.
Evaluating the proportion of people who are infected with the new coronavirus and who are immune is essential for formulating effective disease prevention and control strategies to reduce the possibility of future pandemics.
Since people with mild infections may not seek medical attention, and asymptomatic people are usually not tested, the number of confirmed cases of new coronary disease will be very different from the actual number of infections.
It is clear that asymptomatic infections account for most of the new coronavirus infections.
The results show that 437 (82%) of the 532 new coronavirus antibody-positive people are asymptomatic, which is higher than the estimated value of 40-45% in the past global reports.
The researchers analyzed that if the seroconversion rate can accurately reflect the exposure to the new coronavirus, the obvious difference between the low number of cases and the high seroconversion rate indicates that most of the seroconversion rate is produced by asymptomatic infection.
Anti-coronavirus antibodies.
Regarding the recall bias when the subjects reported whether they had symptoms in the past 5 months, the researchers said that because Wuhan took very strict measures to identify cases at that time, Wuhan citizens paid great attention to recording their own during the outbreak.
Symptoms, therefore, this study will not obviously misjudge whether there are symptoms.
The level of neutralizing antibody remained stable for 9 months.
The study found that in April 2020, only 40% of antibody-positive people produced neutralizing antibodies (functional antibodies that can effectively fight the virus).
The proportion of people with neutralizing antibodies did not see a significant decrease during the two follow-up periods: 45% in June 2020; 41% in October-December 2020.
In addition, the neutralizing antibody analysis of 335 participants who participated in all three follow-ups revealed that the level of neutralizing antibody did not decrease significantly within 9 months.
The positive rate of antibodies in various districts of Wuhan, 4 districts exceeded the city’s average level.
Neutralizing antibodies remained relatively stable 9 months after infection, indicating that once effective humoral immunity to the new coronavirus is stimulated, the effectiveness can last for a long time.
Compared with confirmed patients and symptomatic infections, asymptomatic infections have lower antibody levels.
These findings undoubtedly have hinting significance for the evaluation of the protection time effect of the new crown vaccine.
And it has guiding significance for the future precision prevention and control work.
The concurrent review stated that the article was a landmark study written by Richard Strugnell, an internationally renowned microbiology and immunology expert, and highly praised the study.
In his commentary, Richard pointed out that this study has given people a deeper understanding of the dynamic changes of serum antibodies in patients with new crown infections: it emphasizes the importance of effective new crown vaccines at the population level to control the disease, which can be described as a description of new crown virus infections.
And an important milestone in understanding the immune status under a pandemic.
Typesetting: Physician News Editor: Physician News Review: Xu Fengyan For more content, please click: "One Woman Gets Married More", "Polygamy", the establishment of affiliated hospitals is popular to watch out for the chaos behind the enclosure National Liver Love Day | "Little Slim Man" also has Fatty liver, scientific weight loss method will make your liver go greasy! The "Physician Daily" award-winning survey is waiting for you to participate in the "Physician Daily" submission Public email: yishibao2017@163.
com [Note] Some pictures are from the Internet and WeChat Moments Dear image authors, hello, the Physician Daily is ready for you For the contribution fee, please contact the editor on duty: 010-58302828-6808.
Currently 1130000+ doctors have been paying attention to join us
After the study was unblocked in Wuhan, a rigorous multi-stage cluster random sampling method was used to test representative samples of nearly 10,000 Wuhan residents for new coronavirus antibodies, revealing the dynamic changes of serum antibodies in patients with new coronavirus.
Academician Wang Chen’s team published a study in the “Lancet” that the positive rate of COVID-19 antibodies in the Wuhan population was 6.
9%.
The study showed that among 9542 subjects, 532 were positive for antibodies to the new coronavirus and the population’s antibody positive rate was 6.
9%.
Academician Wang Chen, the lead author of the article, said that there is a big difference between the number of confirmed cases of new crowns in countries and regions around the world and the number of infections estimated based on the seropositive rate of the population.
The new crown seroepidemiology papers published in many countries around the world show that the ratio of the two ranges from several times to dozens of times, and more than 10 times.
For example, Los Angeles is 43.
5 times, the Netherlands is 30 times, and this study is 12.
4 times.
The main reasons include that most of the infected people are asymptomatic and mildly ill, plus the psychology and behavior of the infected people, the local virus nucleic acid detection capacity at the time of the epidemic, nucleic acid screening strategies, nucleic acid sampling methods, laboratory testing methods, etc.
As a result, the positive rate of antibodies is much higher than the incidence rate reported locally, and the number of infections calculated based on the positive rate of seroantibodies is also much higher than the number of diagnosed cases.
Evaluating the proportion of people who are infected with the new coronavirus and who are immune is essential for formulating effective disease prevention and control strategies to reduce the possibility of future pandemics.
Since people with mild infections may not seek medical attention, and asymptomatic people are usually not tested, the number of confirmed cases of new coronary disease will be very different from the actual number of infections.
It is clear that asymptomatic infections account for most of the new coronavirus infections.
The results show that 437 (82%) of the 532 new coronavirus antibody-positive people are asymptomatic, which is higher than the estimated value of 40-45% in the past global reports.
The researchers analyzed that if the seroconversion rate can accurately reflect the exposure to the new coronavirus, the obvious difference between the low number of cases and the high seroconversion rate indicates that most of the seroconversion rate is produced by asymptomatic infection.
Anti-coronavirus antibodies.
Regarding the recall bias when the subjects reported whether they had symptoms in the past 5 months, the researchers said that because Wuhan took very strict measures to identify cases at that time, Wuhan citizens paid great attention to recording their own during the outbreak.
Symptoms, therefore, this study will not obviously misjudge whether there are symptoms.
The level of neutralizing antibody remained stable for 9 months.
The study found that in April 2020, only 40% of antibody-positive people produced neutralizing antibodies (functional antibodies that can effectively fight the virus).
The proportion of people with neutralizing antibodies did not see a significant decrease during the two follow-up periods: 45% in June 2020; 41% in October-December 2020.
In addition, the neutralizing antibody analysis of 335 participants who participated in all three follow-ups revealed that the level of neutralizing antibody did not decrease significantly within 9 months.
The positive rate of antibodies in various districts of Wuhan, 4 districts exceeded the city’s average level.
Neutralizing antibodies remained relatively stable 9 months after infection, indicating that once effective humoral immunity to the new coronavirus is stimulated, the effectiveness can last for a long time.
Compared with confirmed patients and symptomatic infections, asymptomatic infections have lower antibody levels.
These findings undoubtedly have hinting significance for the evaluation of the protection time effect of the new crown vaccine.
And it has guiding significance for the future precision prevention and control work.
The concurrent review stated that the article was a landmark study written by Richard Strugnell, an internationally renowned microbiology and immunology expert, and highly praised the study.
In his commentary, Richard pointed out that this study has given people a deeper understanding of the dynamic changes of serum antibodies in patients with new crown infections: it emphasizes the importance of effective new crown vaccines at the population level to control the disease, which can be described as a description of new crown virus infections.
And an important milestone in understanding the immune status under a pandemic.
Typesetting: Physician News Editor: Physician News Review: Xu Fengyan For more content, please click: "One Woman Gets Married More", "Polygamy", the establishment of affiliated hospitals is popular to watch out for the chaos behind the enclosure National Liver Love Day | "Little Slim Man" also has Fatty liver, scientific weight loss method will make your liver go greasy! The "Physician Daily" award-winning survey is waiting for you to participate in the "Physician Daily" submission Public email: yishibao2017@163.
com [Note] Some pictures are from the Internet and WeChat Moments Dear image authors, hello, the Physician Daily is ready for you For the contribution fee, please contact the editor on duty: 010-58302828-6808.
Currently 1130000+ doctors have been paying attention to join us
