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MiniPEG-PNA

 Last Update: 2021-02-26
 Source: Internet
 Author: User

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properties water polarity

b12 water soluble

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Peptide nucleic acids (PNAs) are attractive, as compared to other classes of oligonucleotides that have been developed todate, in that they are relatively easy to synthesize and modify, hybridize to
DNA
and RNA with high affinity and sequenceselectivity, and are resistant to enzymatic degradation by proteases and nucleases; however, the downside is that they areonly moderately soluble in aqueous solution. Herein we describe the protocols for synthesizing the second-generation γPNAs,both the monomers and oligomers, containing MiniPEG side chain with considerable improvements in water solubility, biocompatibility,and hybridization properties.

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