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miRNA plays an important regulatory role in the interaction between plants and pathogenic microorganisms.
usually mature miRNAs enter the shear complex (RISC) of the AGO protein, negatively regulating gene expression by guiding the cutting of target mRNA or inhibiting protein translation.
previous studies have shown that rice AGO18 proteins can bind to specific binding miRNA members and participate in the resistance response process of rice striped leaf dead virus (RSV), but AGO18 does not have mRNA shearing function, so how AGO18 affects the mechanism of rice anti-RSV by binding specific miRNA is worth exploring.
Cao Xiaofeng Of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences and Li Yi Laboratory, a professor at Peking University's School of Life Sciences, used molecular biology, genetics, and bioinficiology to discover a single leaf plant-specific, RSV-infested inhibited rice negative regulatory disease resistance factor miR528, miR528 can be AGO 18 competitive binding, inhibit the miR528 into the RISC shear complex, thereby releasing miR528 target mRNA AO, assailative hematric acid oxidase AO by regulating the plant body's redox steady state, thereby promoting the accumulation of reactive oxygen (ROS) in the plant and thus starting the downstream antiviral path.
the study revealed the disease resistance mechanism of miR528 and its regulated target gene in the process of rice-virus interaction.
The results of the study, published in Nature Plants, DOI:10.1038/nplants.2016.203), were written by Li Yi and Cao Xiaofeng, co-authors Wu Jianguo, postdoctoral student of The Li Yi Research Group, Yang Rongxin, and Yang Zhixuan, Ph.D. graduate student at Peking University.
also involved in the research work of the Institute of Genetic Development of the Chinese Academy of Sciences, the research group and Tsinghua University Professor Qi Yijun team.
the research has been funded by the National Natural Science Foundation of China.
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