"Miracle medicine" is unusual. Aspirin can inhibit the proliferation of tumor cells

Author: what kind of medicine is Tang Jinghong aspirin? Some people call it "miracle medicine" It can be regarded as a legend in the history of human medicine Aspirin was first widely used as an analgesic and antipyretic drug, and then its side effect, antiplatelet aggregation, made it used in the field of vascular diseases to solve thrombosis At present, aspirin is the recommended medicine for secondary prevention of cardiovascular and cerebrovascular diseases But with the in-depth study of aspirin, scientists found that its role is not only in the field of vascular disease, but also in the prevention of chronic inflammatory diseases, such as cancer, Alzheimer's disease, Parkinson's disease and arthritis Researchers from Hope City in the United States conducted a series of comprehensive and systematic in vivo animal experiments, and then used 3D mathematical modeling to determine the pharmacokinetics of aspirin on the growth and anti-cancer effect of colorectal cancer The study found that with the increase of aspirin dosage, cell death rate increased, while cell division rate decreased, which means that tumor cells are more likely to die and not spread The study was published January 6 in the journal carcinogenesis Https://doi.org/10.1093/carcin/bgz195 four colorectal cancer cell lines were tested with different doses of aspirin (0, 15, 50 and 100mg / kg) On the 3rd, 5th, 7th, 9th and 11th day, the tumor growth of three mice in each treatment group was analyzed Then 3D mathematical modeling analysis was performed to assess cell division and mortality and their effects on aspirin mediated tumor growth The effect of aspirin on the regression of xenografts in animal models showed that aspirin reduced the cell division rate of all cell lines in a dose-dependent manner, accompanied by the increase of cell mortality, and increased the percentage of cells with apoptosis in all cell lines The 3D model of tumor growth showed that aspirin reduced the formation of tumor community, thus inhibited the growth of tumor In addition, the results of this study provide epidemiological data for the protective effect of aspirin in colorectal cancer patients Is the "myth" of aspirin still going on? I believe that with the deepening of research and the enrichment of data, aspirin will bring us more surprises in the future Reference: [1] a comprehensive in vivo and mathematicmodeling based kinetic characterization for aspirin induced prevention incremental cancer