MIT scientists have discovered for the first time a biological mechanism that controls DNA molecular kinks.

MIT scientists have discovered for the first time a biological mechanism that controls THE kinks of DNA molecules, proving that kinks on the same DNA molecule can change from rest to movement, according to a recent report on the Massachusetts Institute of Technology(MIT).
this result will improve the accuracy of gene sequencing technology.
DNA as a classic poly-long chain molecule, and natural things, like all long and thin objects, with self-formation of the "characteristics."
this DNA kink is also present in living cells, the cells also come with a specific topology enzyme that can "untie" the knot.
and the MIT team this time proposed a new way to unlock the kinks of extracellular DNA.
the study leader, MIT chemist Patrick Doyle, and his team have long been involved in the physics of polymer kinks.
DNA is easier to observe under a microscope, and its characteristics make it easy to tie, thus becoming an important object of study.
, the team, using special DNA molecular stretching techniques and imaging observations of DNA kinks, have for the first time discovered a biological mechanism that determines the movement or stationary state of DNA kinks on nucleic acid chains. Patrick Doyle, a
, said polymer physicists had speculated that the kinks could be fixed, but there was no good model system to verify this.
this time, they proved that kinks on the same DNA molecule can change from stillness to moving.
once the environment is changed, the kinks stop;
the discovery offers hope that the dna kinks will not only help researchers improve the accuracy of gene sequencing techniques, but also promote the formation of DNA kinks, slowing down the speed at which DNA molecules pass through the sequencing system, thereby enhancing the ability of sequencing technology.
, demetriomaki Makalov, a scientist at the University of Texas at Austin, said the experiment was the first to show that DNA kinks, like daily cords, can be fixed under tension.
, the experiment provides important insight into molecular-level friction, a phenomenon that has not been well understood.
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