MNFR: Afraid of dementia when you grow old?

Diet is considered to be an important regulatory factor for the decline of the body's cognitive function and the occurrence of dementia, but the existing evidence is still scattered and often inconsistent
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Recently, a research report entitled "Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12-Year Prospective Study" was published in the international journal Molecular Nutrition & Food Research.
Scientists from the University of Barcelona and other institutions approved Studies have found that a diet rich in plant-based products may reduce the risk of cognitive impairment and dementia in the elderly
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Research shows that a diet rich in plant-based products may reduce the risk of cognitive impairment in the elderly.
Image source: University of Barcelona This research is part of the "Healthy Diet for Healthy Living" Joint Research Project (JPI HDHL) , The researchers studied 842 elderly participants over the age of 65 who lived in Bordeaux and Dijon
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The researchers analyzed the relationship between the participants’ dietary composition metabolism, intestinal flora, endogenous metabolism, and cognitive impairment.
The researchers stated that what we analyzed in the research cohort was the risk process of cognitive impairment caused by diet.
The regulatory role played in
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Research results show that there is a clear correlation between these processes and specific metabolites
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The results of the study reveal that there may be a relationship between the metabolism of metabolites from cocoa, coffee, mushrooms, and red wine and foods rich in polyphenols (such as apples, cocoa, green tea, blueberries, oranges, or pomegranates) and cognitive impairment in the elderly.
It is a protective association
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Analysis of the participants’ plasma samples showed that certain metabolites may be related to the development of cognitive impairment and dementia
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For example, as biomarkers of coffee and cocoa intake, 2-furoylglycine and 3-methylanthine have a certain protective effect, while the saccharin produced from the intake of artificial sweeteners is related to the impairment of the body's cognitive function
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Image source: https://onlinelibrary.
wiley.
com/doi/10.
1002/mnfr.
202100606 Researcher Professor Merce Pallas said that the research in this article reveals the relationship between impaired cognitive function, microbiota and food metabolism, and endogenous metabolism.
The correlation between them is essential for the development of preventive and therapeutic strategies to help improve the body’s cognitive health
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Therefore, changes in life>
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Researchers believe that a large intake of fruits, vegetables, and plant-based diets may provide the body with polyphenols and other biologically active compounds, thereby helping to reduce the risk of cognitive decline due to aging
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In summary, the results of this article provide researchers with new insights into early metabolic events related to the risk of cognitive decline in the interaction of diet, intestinal flora and endogenous metabolism, which may be expected to help identify the development of new types of prevention The potential targets of sexual and therapeutic strategies to protect the body’s cognitive health
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References: [1] Raúl González-Domínguez, Pol Castellano-Escuder, Francisco Carmona, et al.
Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12-Year Prospective Study, Molecular Nutrition & Food Research(2021).
DOI: 10.
1002/mnfr.
202100606 Source | Bio Valley Editor | Swagpp Click below "read original text" to download Metz Medical APP