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Modulation of the Expression Level of Human Acidic Lipases by Various Signal Peptides

 Last Update: 2020-11-25
 Source: Internet
 Author: User

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Mammalian acidic lipases belong to a family of lipases that share the ability to maintain activity under acidic conditions. This family includes pre-duodenal lipases and lysosomal lipase and shows no sequence homology with other known lipase families (
1
,
2
). Human gastric lipase (glycerol ester hydrolase, EC 3.1.1.3, HGL) is secreted by chief cells of the fundic part of the stomach (
3
) where it initiates the digestion of triacylglycerols (
4
). Human lysosomal acid lipase (HLAL , EC 3.1.1.13) hydrolyzes cholesteryl esters and triglycerides that are delivered to the lysosomes by low density lipoprotein receptor-mediated endocytosis (
5
).

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