Mol Cell Biol: A glitch in DNA replication in cells may hopefully help develop new treatments for cancer.

In a recent study published in the international journal, scientists from the University of Southern California and others have conducted in-depth studies of living cells to find that the special systems in cells that prevent disease-related genetic damage can sometimes fail so badly that they can function without themThis seems to be a contradictory finding because it challenges the idea that tiny protein guards for cell division are always able to protect cells, but this paper shows that they can sometimes show signs of dysfunctionFILE PHOTO: The results of this paper are important for the treatment of cancer And the failure of replication can lead to the occurrence of other genetic diseases, including birth defects, autism and nerve damage, and the ability of the body to produce new cells is critical to maintaining the proper functioning of tissues and organsThe researchers say we're very interested in studying how replication problems in cells can induce bad things in cells, such as cancer, in which we use split yeast to study that their chromosomes are similar to humans using the same genes to maintain the function of these chromosomes and to be an important model for researchers to study cell divisionIn the article, the researchers reveal how cells react to defects monitored by an important gene called an important gene that functions like a guard in replication, and that a similar gene called a checkpoint gene in the human body ensures that the gene stops dividing the cell until the problem is repaired when it is successfully replicated before the cell dividesIn addition, if there is no proper replication of cells will not be divided or there will be fatal consequencesCancer therapy often combines a drug that blocks replication with a compound that blocks checkpoints, which, like a poison, can drive tumor cells into a lethal division phase; the researchers found that active checkpoints often promote abnormal cell division and, surprisingly, when the researchers rejected the replication checkpoint, the cells that mutated did not divide because another damage control mechanism would initiate an unnecessary cell division processSo why is a gene that tries to help maintain cell health be so confusing that it can cause permanent damage to tissues and organs? In some cases the checkpoint seems to be "blindfolded" and continues to do its job Researchers say we analyzed a special replication defect that seems to produce a perfect cell storm and the checkpoint doesn't know how to deal with it that will do everything it can to protect cells but actually cause the cells to slide into a deadly division processThe findings may help researchers understand how cells work inside and how to improve cancer therapies to better help treat multiple types of cancer patients() Original origin: