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    Home > Active Ingredient News > Immunology News > Mol Cell: How the new coronavirus destroys the lungs in a short time

    Mol Cell: How the new coronavirus destroys the lungs in a short time

    • Last Update: 2021-03-03
    • Source: Internet
    • Author: User
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    January 30, 2021 /--- What effect does the SARS-CoV-2 virus have on our lung cells in the first few hours of infection if scientists know for sure? Can they use this information to find drugs that completely stop the virus from replicating? The discovery that several existing FDA-approved drugs, including some originally designed to fight cancer, could prevent the development of coronavirus suggests the answer is yes.
    team of researchers at Boston University tried to answer these questions.
    they infected thousands of human lung cells with the SARS-CoV-2 virus, and then accurately tracked what happened to all of them in the first few minutes after infection.
    (Image source: www.pixabay.com) shows that the BU team has revealed the most comprehensive picture yet of all molecular activity triggered inside lung cells at the start of coronavirus infection.
    they also found that at least 18 existing FDA-approved drugs could be re-used to fight COVID-19 infection shortly after the infection.
    , five of these drugs reduced the spread of coronavirus in human lung cells by more than 90 percent.
    their findings were recently published in the journal molecular cell.
    "What sets this study apart is that we observed the early stages of infection just an hour after the virus infected lung cells.
    s shocking that the virus has begun to damage cells so early in the infection process," said Elke Mühlberger, a virologist at BU's NEIDL, one of the study's senior researchers.
    the most striking aspect is how many molecular pathways the virus affects," said Andrew Emili, director of the BU's CNSB, another senior researcher on the study.
    the virus did completely reshape lung cells.
    viruses cannot replicate themselves because they lack the molecular mechanisms to make proteins, which is why they rely on infected cells to hijack the internal mechanisms of cells and use them to spread their own genetic material.
    SARS-CoV-2 completely alters the metabolic processes of cells, even destroying the cell's nucleofilm within three to six hours of infection.
    cells infected with the deadly Ebola virus do not show any significant structural changes at these early stages of infection, and the nucleus remains intact even in the late stages of infection," said
    Mühlberger.
    " nucleofilm surrounds the nucleosis, which holds most of the cell's genetic information and controls and regulates normal cellular function.
    the condition of the entire cell deteriorates rapidly as SARS-CoV-2 destroys the nucleocles.
    under siege, these cells die, and these cells usually play a role in maintaining the necessary gas exchange of oxygen and carbon dioxide that occurs while we breathe.
    as cells die, they also send out distress signals that promote inflammation, triggering a series of biological activities that accelerate cell death and eventually lead to pneumonia, acute respiratory distress and lung failure.
    (Bioon.com) Source: corona Howvirus damages lung cells within mere hours Original source: Ryan M. Hekman et al, Actionable Cytopathic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2, Molecular Cell (2020). DOI: 10.1016/j.molcel.2020.11.028
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