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June 15th, 2021 // --Mammal DNA base excision repair (BER) is accelerated by PARPs (poly(ADP-ribose) polymerases) and scaffold protein XRCC1 Yes, PARPs can be used as a sensor to detect single-strand break intermediates, but the key role it plays during BER is currently unknown to researchers
Molecular Cell scientists from the University of Sussex and other institutions have studied the mechanism of DNA damage in the body and discovered specific proteins that can induce certain cancerous tumors
Image source: https:// in a very good day, the DNA in our body is constantly being destroyed, with scars, scratches and breaks.
PARPs can act as a special marker to indicate the point of error.
XRCC1 can prevent PARP1 from being captured during DNA base excision repair
Image source: Annie A.
Molecular Cell
In the article, the researchers compared cells lacking the XRCC1 gene with cells lacking PARP and cells lacking these two proteins, and found that without XRCC1 patrols, PARP traps would continue to accumulate like landmines
The researchers pointed out that these findings indicate that XRCC1 may be a key factor in solving the PARP trap, and it may be used as a determinant to clarify the therapeutic properties of PAPR inhibitors in the treatment of hereditary breast and ovarian cancer syndromes.
XRCC1 may be a key factor in solving the PARP trap, and it may be used as a determinant to clarify the therapeutic effects of PAPR inhibitors in the treatment of hereditary breast and ovarian cancer syndromes
Original source:
Annie A.
Annie A.
Demin, Kouji Hirota, Masataka Tsuda, et al.
XRCC1 prevents toxic PARP1 trapping during DNA base excision repair , Molecular Cell (2021).
DOI: 10.
1016/j.
molcel.
2021.
05.
009 XRCC1 prevents toxic PARP1 trapping during DNA base excision repair Molecular Cell