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Type 2 diabetes (T2D) is a chronic hyperglycemic state characterized by decreased glucose-stimulated insulin secretion (GSIS) and increased insulin resistance in insulin target tissues
.
The initiation of pathogenic mechanisms may be multifaceted, mainly affecting any tissue involved in glucose homeostasis, including pancreatic islet cells, liver, muscle, adipose tissue or the autonomic nervous system
Glucose-stimulated decrease in insulin secretion (GSIS) and increased insulin resistance in insulin target tissues are characteristic
Methods: We used a systems biology method to characterize the plasma lipidomes of C57Bl/6J, DBA/2J and BALB/cJ mice under different nutritional conditions, as well as their islets and liver transcriptomes
.
We look for the correlation between blood lipids and tissue gene expression
Results: We found a strong correlation between plasma triacylglycerols (TAGs) and pancreatic islet gene modules
.
Pancreatic islet gene module is a key regulator of glucose and lipid regulation of insulin secretion, as well as a key regulator of insulin signaling pathway
Figure 1 Metabolic phenotype, liposome phenotype and transcriptome phenotype; A.
Test protocol
.
B.
Figure 1 Metabolic phenotype, liposome phenotype and transcriptome phenotype; A.
Figure 2 The correlation of TAGs and SMs with gene modules and pancreatic islet function pathways; A.
Heat map of lipid-gene module correlation
.
The color code of the lipids is shown on the right side of the figure
Figure 2 The correlation of TAGs and SMs with gene modules and pancreatic islet function pathways; A.
TAGs are biomarkers of the hepatocyte axis, which link liver cell oxidation with the quality of cell function and insulin secretion
Sánchez-Archidona AR, Cruciani-Guglielmacci C, Roujeau C,et al.
Plasma triacylglycerols are biomarkers of ß-cell function in mice and humans.
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