Mol Neurobiol:Drinking makes people silly, and studies have shown that drinking alcohol accelerates the onset of Alzheimer's disease and makes its symptoms worse.

Alzheimer's disease (AD), commonly known as Alzheimer's disease, is a type of degenerative lesions of the central nervous system that occur mainly in the elderly and are characterized by sexual cognitive impairment and behavioral impairment.
, the cause of Alzheimer's disease is not entirely clear, except in a few cases involving genetic mutations.
, despite the scientific community's efforts in Alzheimer's disease, there is still no very effective treatment to prevent or cure it.
August 21, 2020, researchers at the Center for Immunization and Inflammation at the Feinstein Institute of Medicine in the United States published a review paper in the journal Molecular Neurobiology entitled: Potential Role of Extracellular CIRP in Alcohol-Induced Alzheimer's Disease.
paper reveals that excessive alcoholism may be associated with the onset and severity of Alzheimer's disease.
specifically, under the influence of excessive alcohol, the tau protein will develop abnormal phosphatation and loss of normal biological function, thus promoting the development of Alzheimer's disease. the accumulation of
extracellular geriatric spots is one of the main neuropathological characteristics of Alzheimer's disease, which contains β-amyloid protein aggregates and neurofibromus entanglements (NFTs) in neuron cells, while NFTs contain a highly phosphatized and abnormally aggregated micro-tube-related protein, tau protein.
In fact, the density of abnormally high phosphate tau protein in the brain and its typical space-time progression are highly relevant to cognitive decline, so identifying mechanisms for pathological tau protein phosphatization is critical to developing new and effective strategies for the prevention or treatment of Alzheimer's disease.
Dr Max Brenner, an assistant professor at the Feinstein Institute and one of the study's authors, said: "Previous studies have shown that frequent and heavy drinking is associated with early onset and exacerbation of Alzheimer's disease, and there have also been studies showing that alcohol consumption is associated with atrophy of the brain cortical system in Alzheimer's disease, with people who drink alcohol having a higher risk of developing Alzheimer's disease and a younger onset.
" study was designed to shed light on specific proteins that play a key role in the abnormal aggregation of tau proteins.
Brenner and colleagues first found that extracellular cold-induced RNA binding proteins (eCIRP) are key vectors of memory impairment caused by excessive drinking.
, they reasoned that eCIRP may play a key role in the relationship between alcohol and Alzheimer's disease.
of alcohol, Alzheimer's disease, and eCIRP, CIRP is usually present in the nuclei of cells and can help regulate the type and number of proteins produced by each cell.
, however, when cells detect potential threat factors, they release molecules like eCIRP to alert other nearby cells to start preparing their defenses to overcome stress conditions.
For example, in patients with acute alcoholism, alcohol spreads throughout the brain, and alcohol-stimulated brain cells release eCIRP, which binds to specific membrane proteins in other cells, activating the associated cellular signaling pathlines that trigger cascading reactions that eventually lead to neuroinstration and cognitive impairment.
, the researchers looked at the potential contribution of eCIRP to alcohol-induced Alzheimer's disease by targeting tau phosphate.
, they also considered the effects of eCIRP on neuron death and neurogenesis, which in turn linked alcohol to the development of Alzheimer's disease.
confirms that eCIRP is a key molecule linking Alzheimer's disease to acute alcoholism, neuroinstation and tau phosphate.
The potential mechanisms of alcohol-induced small glial cell eCIRP to promote the development of Alzheimer's disease have long been shown that long-term alcohol exposure can lead to abnormal phosphate of the neural tau protein in the hema body and induce the occurrence of Alzheimer's disease, and now this study sheds light on the key molecular mechanisms of this process, and the future targeting of eCIRP may become a new treatment strategy for preventing and mitigating alcohol-induced Alzheimer's disease.
in all, this review builds a link between eCIRP, long-term alcohol exposure, and Alzheimer's disease, suggesting that excessive alcoholism may accelerate the onset of Alzheimer's disease and make its symptoms worse! More importantly, the study also opens up new avenues for the development of prevention or treatment of Alzheimer's disease.
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