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    Home > Active Ingredient News > Endocrine System > Mol Nutr Food Res: AvoB prevents fatty toxicity and improves insulin sensitivity in diet-induced obesity.

    Mol Nutr Food Res: AvoB prevents fatty toxicity and improves insulin sensitivity in diet-induced obesity.

    • Last Update: 2020-10-13
    • Source: Internet
    • Author: User
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    The purpose of this study was to assess the effects of avogo-derived fatty acid oxidation (FAO) inhibitor AvoB on glucose and fat metabolism in diet-induced obesity (DIO) models and in vitro fat toxicity models.
    , the study also determined its safety in humans, and the results have been published online in Mol Nutr Food Res.
    gave mice a high-fat diet (HFD) for 8 weeks.
    , oral AvoB or vehicle is served twice a week for 5 weeks.
    results showed that AvoB inhibited FAO, resulting in improved glucose tolerance, glucose utilization and insulin sensitivity.
    the effects of AvoB on the metabolism of β cells and C2C12 muscle tubes in in-body.
    found that AvoB inhibited FAO, increased glucose oxidation, leading to a decrease in mitochondrial reactive oxygen species, respectively, to improve the insulin response of the C2C12 muscle tube and insulin secretion of INS-1 (832/13) cells.
    researchers conducted a randomized, double-blind, placebo-controlled clinical trial in healthy human participants to assess the safety of taking AvoB (50 mg or 200 mg per day for 60 days).
    found that AvoB was well-to-do and not accompanied by any dose-limiting toxicity.
    , the results show that there are currently no safe and effective drugs to suppress FAO and improve THEO-related pathology.
    AvoB's mechanism of function and good safety highlight its nutritional and clinical importance.
    .
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