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Healthy sleep is a basic physiological need
However, the deep restorative sleep required to consistently achieve optimal physical health and cognitive performance can be difficult due to life>
One of the most perplexing questions in sleep biology is how the brain regulates deep sleep
Now, a newly published study led by researchers at Harvard Medical School at the VA Boston Health Care System provides key clues to this longstanding mystery
The study was performed in mice and was published April 26 in the journal Nature Communications
The team focused on neurons in the thalamus, an area of the brain responsible for regulating functions such as sleep and wakefulness
If replicated in further animal models, these findings could lay the groundwork for designing therapeutics targeting this protein to induce deep sleep
"Our findings represent an important step toward pinpointing the molecular basis of sleep regulation and point to an alternative pharmaceutical strategy for promoting natural, restorative sleep," said study senior investigator Radhika Basheer, HMS and co-author of the study.
New treatments are urgently needed
"We believe our findings lay the groundwork for the development of a new class of sleep drugs that can enhance the maintenance of deep sleep by enhancing delta wave oscillations," added Basheer, who with colleague Ritchie Brown Leading the study, he is an associate professor of psychiatry at HMS
Courtesy of Harvard Medical School
