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    Home > Active Ingredient News > Digestive System Information > Molecules: Lycopene: Think I can only fight prostate cancer?

    Molecules: Lycopene: Think I can only fight prostate cancer?

    • Last Update: 2021-09-19
    • Source: Internet
    • Author: User
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    Lycopene is a cyclic linear carotenoid.
    Unlike beta carotene, it will not be converted into vitamin A in the body

    .
    Lycopene is a heat-stable carotenoid, cooking will not damage it; on the contrary, heating can make them more easily absorbed by the body

    .

    Many studies have shown that a large intake of tomatoes can reduce the incidence of cancer
    .
    Given that tomato is one of the most consumed vegetables in the world, these results are very important

    .
    Several studies have shown that lycopene seems to have a
    preventive effect on prostate cancer
    .
    In addition to antioxidant effects,
    lycopene can also inhibit proliferation and induce apoptosis, and reduce the metastatic potential of prostate cancer cells
    .
    This article focuses on analyzing the possible effects of lycopene on different aspects and steps of tumorigenesis and progression

    .

    Preventing lycopene can also inhibit proliferation and induce apoptosis,

    1.
    Antioxidant properties of lycopene

    1.
    Antioxidant properties of lycopene

    The antioxidant properties of lycopene may be the reason for its anti-cancer and prevention of various chronic diseases
    .
    Lycopene can regulate the effects of lipid peroxidation and DNA damage, antioxidant response element (ARE) and Nrf2 (nuclear factor E2-related factor 2), cytochrome P450 expression, inhibit iNOS and COX-2 expression, and down-regulate
    NF -kB regulation and so on
    .

    NF-kB regulation and so on
    .

    2.
    Anti-cancer properties of lycopene

    2.
    Anti-cancer properties of lycopene

    Oxidative stress is one of the key factors associated with increased cancer risk, and the antioxidant properties of lycopene can effectively "purify" a series of free radicals
    .
    We can also observe the ability of lycopene to inhibit the proliferation of cancer cells in different types of cancer cells
    .
    Lycopene can cause a decrease in the level of cyclin D1 in cancer cells, and a corresponding increase in p53 and p21 proteins
    .
    Lycopene and other carotenoids regulate
    the expression and/or phosphorylation of proteins such as Bcl-2, Bad, Bid and Bax, thereby inducing cell apoptosis
    .

    The antioxidant properties of lycopene can effectively "purify" a series of free radicals
    .
    We can also observe the ability of lycopene to inhibit the proliferation of cancer cells in different types of cancer cells
    .
    We can also observe the ability of lycopene to inhibit the proliferation of cancer cells in different types of cancer cells
    .
    Lycopene can cause a decrease in the level of cyclin D1 in cancer cells, and a corresponding increase in p53 and p21 proteins
    .
    Lycopene and other carotenoids regulate
    the expression and/or phosphorylation of proteins such as Bcl-2, Bad, Bid and Bax, thereby inducing cell apoptosis
    .

    There is increasing evidence that lycopene can regulate IGF-1, leading to a decrease in the growth of cancer cell lines and reducing IGF-1-stimulated cell growth in endometrial cancer, breast cancer, and lung cancer
    .
    Cancer cells exhibit abnormalities in the
    cholesterol biosynthetic pathway
    .
    In different tumor cell lines, dose-dependent lycopene treatment can reduce the intracellular levels of total cholesterol and reduce HMG-CoA (hydroxymethyl gluconyl-isoenzyme A)

    .

    Breast cancer cholesterol

    Prostate cancer ranks second in cancer-related mortality in the United States
    .
    There is a large amount of epidemiological evidence showing the inverse relationship between consumption of fan and derivative edible products and susceptibility to prostate cancer

    .
    Lycopene can act as an anticancer agent by preventing cell proliferation and/or apoptosis induction, and this beneficial effect on other organs is still being studied

    .

    Current studies have found that several gene mutations are associated with the development of prostate cancer, and these mutations control cell differentiation and growth
    .
    In chronic inflammatory processes, such as bacterial
    infection of the prostate or prostatitis, it may be related to the production of ROS
    .
    This can cause oxidative DNA damage through genetic mutations

    .
    Studies have also shown that the increase in ROS in prostate cancer cells is related to androgens

    .
    Another study using proteomics (iTRAQ) analyzed the protein expression in prostate epithelial cells after lycopene treatment

    .
    Lycopene enhances the production of protective enzymes in the second stage, and the proteins involved in the formation of ROS are reduced
    .
    This indicates that lycopene can minimize the formation of ROS and reduce oxidative stress

    .
    Random clinical trials have also shown that lycopene can reduce PSA levels and affect prostate cell proliferation in patients with prostate hyperplasia or cancer

    .

    Infect

    4.
    Clinical case studies

    4.
    Clinical case studies

    There are still few reports on lycopene and/or tomato and related randomized clinical trials; the Kumar team conducted a second phase of randomized clinical trials to evaluate the safety and treatment effects of clinically diagnosed prostate cancer patients
    .
    The results indicate that in addition to the antioxidant properties of lycopene, some steroid hormone-based mechanisms may also be involved

    .

    diagnosis

    The Van Breemen team reported the results of a randomized controlled clinical trial that did not reveal the effect of lycopene on prostate-specific antigen (PSA) levels or the incidence of prostate cancer
    .
    Compared with the control group, patients taking lycopene had very high lycopene concentrations in plasma and prostate tissue
    .
    However, no significant differences were found in molecular markers of oxidative stress
    .

    The effect of lycopene on the level of prostate specific antigen (PSA) or the incidence of prostate cancer is not revealed
    .
    Compared with the control group, patients taking lycopene had very high lycopene concentrations in plasma and prostate tissue
    .
    However, no significant differences were found in molecular markers of oxidative stress
    .

    The Magbanua soft team conducted a randomized clinical trial on men with a lower risk of prostate cancer to evaluate gene expression and biological pathways after supplementation with lycopene, fish oil or placebo
    .
    The results indicate that these micronutrients regulate candidate pathways in vivo
    .
    For example, androgen and estrogen metabolism, Nrf2 and its mediated stress are all regulated by these micronutrients
    .

    The Magbanua soft team conducted a randomized clinical trial on men with a lower risk of prostate cancer to evaluate gene expression and biological pathways after supplementation with lycopene, fish oil or placebo
    .
    The results indicate that these micronutrients regulate candidate pathways in vivo
    .
    For example, androgen and estrogen metabolism, Nrf2 and its mediated stress are all regulated by these micronutrients
    .

    Benon’s team conducted a ProDiet randomized controlled trial on men at risk of prostate cancer to evaluate the effects of lycopene and green tea
    .
    They suggested that the possibility of lycopene lowering acetone levels may be related to a lower risk of prostate cancer

    .

    In 3 randomized controlled clinical trials, 154 patients with prostate intraepithelial neoplasia or benign prostatic hyperplasia were evaluated for the role of lycopene in the prevention of prostate cancer
    .
    The results showed a decrease in the incidence of prostate cancer, although there was no statistical difference from the control group
    .

    In 3 randomized controlled clinical trials, 154 patients with prostate intraepithelial neoplasia or benign prostatic hyperplasia were evaluated for the role of lycopene in the prevention of prostate cancer
    .
    The results showed a decrease in the incidence of prostate cancer, although there was no statistical difference from the control group
    .

    A meta-analysis studied the effect of tomato-based product intake on reducing the risk of prostate cancer
    .
    This study evaluated 21 studies that involved the daily intake of one or more tomatoes, tomato derivatives, or lycopene supplements
    .
    The results of the study showed that their cancer risk was reduced to a certain extent (11%), and their tomato intake was limited to a high level
    .

    A meta-analysis studied the effect of tomato-based product intake on reducing the risk of prostate cancer
    .
    This study evaluated 21 studies that involved the daily intake of one or more tomatoes, tomato derivatives, or lycopene supplements
    .
    The results of the study showed that their cancer risk was reduced to a certain extent (11%), and their tomato intake was limited to a high level
    .

    A review reported that tomato intake or lycopene plasma levels were negatively correlated with cancer risk at specific anatomical sites
    .
    There is
    no research report that shows that high tomato intake or high plasma lycopene levels increase the risk of cancer
    .
    According to reports, lycopene has a stronger positive effect on prostate cancer, lung cancer and gastric cancer
    .
    In addition, data shows that lycopene has a protective effect on pancreatic cancer , colorectal cancer, esophageal cancer, oral cancer, breast cancer and cervical cancer
    .

    A review reported that tomato intake or lycopene plasma levels were negatively correlated with cancer risk at specific anatomical sites
    .
    There is
    no research report that shows that high tomato intake or high plasma lycopene levels increase the risk of cancer
    .
    According to reports, lycopene has a stronger positive effect on prostate cancer, lung cancer and gastric cancer
    .
    Gastric cancer In addition, data shows that lycopene has a protective effect on pancreatic cancer , colorectal cancer, esophageal cancer, oral cancer, breast cancer and cervical cancer
    .
    Pancreatic cancer

    5 Conclusion

    5 Conclusion

    At present, a large number of epidemiological studies have reported the beneficial effects of fruits and vegetables rich in carotenoids in reducing cancer-related risks
    .
    Although there is a large amount of evidence that lycopene has antioxidant effects and related anti-tumor effects, the biological activities, potential molecular mechanisms and metabolism of carotenoids and lycopene are not yet clear
    .

    At present, a large number of epidemiological studies have reported the beneficial effects of fruits and vegetables rich in carotenoids in reducing cancer-related risks
    .
    Although there is a large amount of evidence that lycopene has antioxidant effects and related anti-tumor effects, the biological activities, potential molecular mechanisms and metabolism of carotenoids and lycopene are not yet clear
    .

    The saint said, "Going to cure the disease
    .
    "
    We encourage increased consumption of healthy tomatoes and other products, which are delicious, beneficial and harmless
    .
    And tomato has long become the “emperor” of the world’s garden.
    It is on the “best vegetables” list.
    It is also
    one of the main foods of the Mediterranean diet , which is known for its health .

    The saint said, "Going to cure the disease
    .
    "
    We encourage increased consumption of healthy tomatoes and other products, which are delicious, beneficial and harmless
    .
    And tomato has long become the “emperor” of the world’s garden.
    It is on the “best vegetables” list.
    It is also
    one of the main foods of the Mediterranean diet
    , which is known for its health .
    Mediterranean diet



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