More than 30 mutations of the new coronavirus have appeared in people with AIDS, and the emergency use of the new coronavirus vaccine has been extended to over 3 years of age. The progress of new coronavirus research in one week

There are more than 30 new coronavirus mutations in an AIDS patient

There are more than 30 new coronavirus mutations in an AIDS patient

Source: MedRxiv

Source: MedRxiv Source: MedRxiv

Recently, in a case report published on the MedRxiv website in the form of a preprint, it was found that a 36-year-old patient with advanced AIDS had a potential new coronavirus mutation
.

The woman was diagnosed with HIV in 2006 and contracted with the new crown virus in September 2020.
Within 216 days of carrying the new crown virus, there were more than 30 mutations in her body, including the mutant strain found in South Africa and similar mutations found in the United Kingdom and Brazil.
Virus strain
.

It is worth noting that this report has not yet been peer reviewed

New coronavirus infection changes the composition of children's flora

New coronavirus infection changes the composition of children's flora

Source: Journal of Genetics and Genomics

Source: Journal of Genetics and Genomics Source: Journal of Genetics and Genomics

Recently, a study published in the Journal of Genetics and Genomics found that the new coronavirus infection changes the composition of the upper respiratory tract and intestinal flora of children
.

In the two months after the child was infected with the new crown, the bacterial flora continued to be unbalanced and fluctuated significantly, even extending to 2 to 3 weeks after recovery and discharge
.

In addition, the upper respiratory tract and intestinal flora of infected children show an asynchronous dynamic evolution trend

There are obvious differences in the coordinated recovery of the upper respiratory tract and intestinal flora between children and adults infected by the new coronavirus.
Children's flora is relatively fragile and vulnerable to interference
.

The long-term impact of the new coronavirus on the development of the upper respiratory and intestinal flora of children, as well as the potential health risks it brings, deserve continuous attention

The new crown epidemic may cause a significant drop in urban crime rates

The new crown epidemic may cause a significant drop in urban crime rates

Source: Nature Human Behavior

Source: Nature Human Behavior Source: Nature Human Behavior

On June 2, a sociological global analysis published in "Nature Human Behavior" found that the home policy implemented globally due to the new crown pneumonia pandemic was the same as that in 27 cities in 23 countries.
The crime rate dropped by 37%
.

The smallest decrease in average was intentional homicide (14%), the largest was robbery (46%) and theft (47%), and burglary (28%), car theft (37%), and assault (35%) also experienced some Down

Stricter restrictions are imposed on movement in public spaces, and the crime rate is expected to drop even more
.

Further research should dig deeper into the longer-term dynamic mechanism of urban crime, use data collected by more cities around the world, and also need to evaluate the impact of city closure measures on crime patterns in specific areas

Research finds that new crown vaccine recipients have lower levels of antibodies against Indian variants

Research finds that new crown vaccine recipients have lower levels of antibodies against Indian variants

Source: the Lancet

Source: the Lancet Source: the Lancet

In a work published in The Lancet on June 3, the latest laboratory data showed that the blood of the vaccinators can identify and fight against the new SARS-CoV-2 delta variant discovered in India for the first time (B.
1.
617.
2) The level of antibodies is on average lower than the level of antibodies against variants previously popular in the UK
.

The results of the study also show that the levels of these antibodies decrease with age and decline over time, which provides evidence to support plans to provide additional vaccination times to vulnerable populations in the fall
.

This is the largest study published to date, investigating the ability of antibodies to neutralize the latest variants of interest induced by vaccines in healthy adults

The age of emergency use of the new crown vaccine has expanded to over 3 years old

The age of emergency use of the new crown vaccine has expanded to over 3 years old

On June 6, the relevant person in charge of the vaccine research and development group of the Joint Prevention and Control Mechanism of the State Council stated that the state approved the expansion of the emergency use age range of the new crown vaccine to over 3 years old
.

Experts have demonstrated the safety and effectiveness of the vaccine used by people aged 3 to 17 years old.

It is understood that Kexing has confirmed through phase I and phase II clinical trials that after vaccinating hundreds of children (3-17 years old), the safety is good, and the level of antibodies produced in children is the same as that of adults.

.

The spread of the new coronavirus variant in Europe in 2020 is related to the resumption of travel

The spread of the new coronavirus variant in Europe in 2020 is related to the resumption of travel

Source: Nature

Source: Nature Source: Nature

In an article published in Nature on June 7, researchers analyzed the virus variant 20E (EU1) detected in Spain in the early summer of 2020 as the main epidemic strain in the European new crown epidemic in the fall of 2020.
The reason
.

The study found that many EU countries resumed travel in mid-June and reached a peak in July and August.
This variant has been exported from Spain to European countries several times through this route, and the pattern of its entry into other countries is consistent with the travel data forecast
.

Studies believe that the rebound of the epidemic in many European countries is partly due to insufficient international travel and insufficient quarantine

The mechanism of the new coronavirus "Alpha" evading the immune system is revealed

The mechanism of the new coronavirus "Alpha" evading the immune system is revealed

Source: New York Times

Source: New York Times Source: New York Times

According to the latest news from the New York Times on the 8th, a new study reveals the way the mutant virus "Alpha (α)" originally discovered in the UK evades the human immune system: a mutation carried by α can make it produce more Orf9b protein , These proteins aggregate on the human Tom70 protein to inhibit the production of interferon and the overall immune response
.
This makes the alpha variant virus become "invisible", not attacked, and more likely to replicate itself
.

Understanding how the virus evolved to escape the immune system will help scientists design better vaccines for COVID-19
.

Anti-aging drugs can reduce mortality in elderly mice infected with coronavirus

Anti-aging drugs can reduce mortality in elderly mice infected with coronavirus

Source: Science

Source: Science Source: Science

On June 8, a preclinical study published in Science showed that anti-aging drugs can significantly reduce the mortality of elderly mice infected with the β-coronavirus, which is closely related to the new coronavirus.
The latest study is It provides a new way to reduce the mortality and severe illness rate of elderly patients with new coronary pneumonia
.

The researchers found that the mortality rate of old mice exposed to mouse beta coronavirus for the first time was close to 100%, while young mice hardly got sick
.
When they treated old mice with anti-aging drugs after infection, they found that the survival rate of these diseased mice increased to 50%
.

The cause of the new coronavirus destroying the lungs revealed

The reason why the new coronavirus destroys the lungs is revealed The reason why the new coronavirus destroys the lungs is revealed

Source: Nature Communications

On June 8, in a work published in Nature Communications, the first detailed atomic-level model of the envelope protein (Envelope protein, E protein) of the new coronavirus was established, which is related to the maintenance of lungs.
A human lung cell connexin called PALS1, which is necessary for the mucosa, binds
.

The model shows how these two proteins interact, helping to explain how the virus causes extensive lung damage in particularly vulnerable patients with new coronary pneumonia, and escapes the lungs to infect other organs
.
The envelope protein of the virus "pulls" the PALS1 protein from their usual work of keeping lung cells tightly connected by binding to the human body's PALS1 protein, which can explain the cause of lung damage caused by the new coronavirus
.
This discovery may accelerate research on drugs that block the serious effects of the disease
.

Another inactivated new crown vaccine in my country was approved for marketing, with 2 doses inoculated throughout the course

Another inactivated new crown vaccine in my country was approved for marketing, with 2 doses inoculated throughout the course

On June 9th, the Covifo new coronavirus inactivated vaccine independently developed by the Institute of Medical Biology of the Chinese Academy of Medical Sciences was put on the market for emergency domestic use
.

The results of phase I and phase II clinical trials show that the vaccine has good safety and immunogenicity.
It can quickly induce the body to produce an immune response after vaccination.
The positive conversion rate of neutralizing antibody and anti-S protein antibody reached 14 days after the full course of immunization.
96% and 99.
33%
.
The results of the cross-neutralization test showed that the antibodies induced by the vaccine have the ability to cross-neutralize the new coronavirus variants from different sources
.

Two doses of Covifo vaccine are given in the whole course, with an interval of 2 to 4 weeks between each dose.
Currently, the age range of people who can be vaccinated is 18 years old and above
.

AstraZeneca's new crown vaccine is linked to slightly increased risk of bleeding disorders

AstraZeneca's new crown vaccine is linked to slightly increased risk of bleeding disorders

Source: Nature Medicine

Source: Nature Medicine Source: Nature Medicine

In a work published online in Nature Medicine on June 9, the research team surveyed 2.
53 million people who had received the first dose of Oxford/Aspen between December 2020 and April 2021.
Scottish adults who received Likang's new crown vaccine or Pfizer/BioNTech's new crown vaccine
.

The results show that the Oxford/AstraZeneca vaccine is associated with a slight increase in the risk of an autoimmune bleeding disorder, which is mainly observed in elderly people with chronic health problems such as coronary heart disease, diabetes or chronic kidney disease
.
In addition, the study found that the risk of arterial thrombosis and bleeding events slightly increased after the Oxford/AstraZeneca vaccine, but there was insufficient evidence that the vaccine was related to cerebral venous sinus thrombosis
.

At the same time, the research team found no evidence between the Pfizer/BioNTech vaccine and the increased risk of these adverse events
.

The evolutionary origin of SARS-CoV-2 and related viruses revealed

The evolutionary origin of SARS-CoV-2 and related viruses revealed

Source: Cell

Source: Cell Source: Cell

On June 9, a research paper published online in Cell describes the metatranscriptomics of 411 bat samples collected from a small geographic area in Yunnan Province, China between May 2019 and November 2020 Research
.
The study identified 24 full-length coronavirus genomes, including four new SARS-CoV-2 related and three SARS-CoV related viruses
.

The Rhinolophus pusillus virus RpYN06 is a close relative of SARS-CoV-2 in most of its genome, although it has a more diverse spike gene
.
The other three SARS-CoV-2 related coronaviruses carry a genetically unique spike gene that can weakly bind to the hACE2 receptor in vitro
.
The study highlights the remarkable diversity of bat coronaviruses in the local area, including close relatives of SARS-CoV-2 and SARS-CoV
.

New crown vaccination can protect unvaccinated people

New crown vaccination can protect unvaccinated people

Source: Nature Medicine

Source: Nature Medicine Source: Nature Medicine

A study in Israel published in Nature Medicine on June 10 showed that the new crown vaccination can not only protect the vaccinated people, but also reduce the risk of infection of the new crown virus in people who have not been vaccinated
.

The researchers analyzed 177 communities with different geographical locations and different vaccination rates.
The results showed that the increase in the vaccination rate among 16-50-year-old adults is comparable to the positive rate of nucleic acid testing in the unvaccinated population under 16 in the same community The negative correlation
.

The higher the rate of vaccination, the lower the positive rate of nucleic acid testing in the unvaccinated population
.
On average, for every 20% increase in the proportion of vaccinated people in a community, the proportion of people who have not been vaccinated in the same community will have a two-fold reduction in nucleic acid test positive
.

Pfizer vaccine is effective against new coronavirus variants found in India

Pfizer vaccine is effective against new coronavirus variants found in India

Source: Nature

Source: Nature Source: Nature

On June 10, in a paper published in Nature, researchers found that after vaccinating with Pfizer's BioNTech new crown vaccine, the serum can neutralize the B.
1.
617.
2 mutant strain and some other mutant strains found in India
.

The study used 20 serum samples from 15 Pfizer BioNTech 2 dose vaccinators and found that compared with the virus strain isolated in January 2020, the serum has lower activity against the mutant strain, especially the B.
617.
1 mutant strain
.
But the serum has a robust neutralizing effect on all tested variants
.

Leave a message here