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    Home > Biochemistry News > Biotechnology News > Most incidental adrenal tumors are non-functional and independent of the patient's age

    Most incidental adrenal tumors are non-functional and independent of the patient's age

    • Last Update: 2022-09-21
    • Source: Internet
    • Author: User
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    A cross-sectional study of more than 25,000 adults found that the prevalence of adrenal tumors in selected communities was 1.
    4 percent
    as screening increased.
    Prevalence increases with age, from 0.
    2% of adults aged 18 to 25 years to 3.
    2%
    of adults over the age of 65.
    However, about 70 percent of tumors were non-functional, meaning they didn't produce additional hormones
    regardless of participants' ages.
    The results of this study were published in the Annals of Internal Medicine
    .

    With the improvement and popularization of screening techniques, the detection rate of occasional adrenal tumors or accidentally discovered nodules that do not cause clinical symptoms has increased
    .
    However, most published literature on the prevalence of adrenal sporadic tumors is based on retrospective surveys of radiodiagnosis in the medical record system, which may underestimate or overestimate the prevalence
    .

    Researchers from the First Affiliated Hospital of Chongqing Medical University conducted a cross-sectional study
    of 25,356 participants undergoing annual health assessments between November 2020 and November 2021.
    The authors report that of all 25,356 participants, 351 were identified with adrenal tumors
    .
    Among them, 337 patients with adrenal tumors were diagnosed with adrenal cortical adenomas and 14 were diagnosed with another benign nodule
    .
    No participants were diagnosed with malignant tumors
    .
    The authors also reported that of the 212 participants who completed endocrine testing, 69.
    3 percent were diagnosed with non-functional adenomas, 18.
    9 percent were diagnosed with cortisol autonomy, 11.
    8 percent were diagnosed with primary hyperaldosteronism, and no participants were diagnosed with pheochromocytoma
    .

    An editorial at the Mayo Clinic highlights that the study provides important insights into the prevalence of adrenal tumors and supports current recommendations
    for universal hormone testing in any patient who stumbles upon an adrenal tumor.
    However, the authors caution that the study's limitations are that 37 percent of participants lack hormone testing, especially since people with declining hormone levels are older and more likely to develop high blood pressure
    .
    Therefore, mild autonomic cortisol secretion and primary hyperaldosteronism may be more prevalent
    in this group.
    Media Contact: For access to the banned PDF file, please contact Angela Collom at acollom@acponline.
    org
    .
    ------------------------------------------------- 2
    。 An cohort study by the Johns Hopkins Bloomberg School of Public Health found that the newly developed Elixhauser (S-Elixhauser) summary comorbidity score was well calibrated and internally validated to predict hospitalization, 30-day and 1-year mortality, but it was better than existing healthcare research and quality agencies (AHRQs) Elixhauser and Charleson summed up the advantages of the score that are unclear
    .
    The report was published in the Annals of Internal Medicine
    .
    Abstract comorbidity scores, such as the Charleson comorbidity Index and the Elixirhauser Comorbidity Index, can both describe the comorbidity burden in observational studies and can be used for prognostic judgments
    .
    The Elixhauser comorbidity indicator set was developed in 1998, but has been modified to include the addition of weighted scores and the expansion of the comorbidity code
    .
    The AHRQ also derived and evaluated model fits for Elixirhauser's summative score to weight individual comorbidities to predict inpatient mortality and all-cause readmissions within 30 days of hospitalized adults
    .
    However, the performance of the summative score in predicting long-term mortality outcomes has not been evaluated and has not been confirmed for use in older adults
    .

    The researchers looked at data from Medicare beneficiaries hospitalized in 2018, including those diagnosed with heart failure, chronic obstructive pulmonary disease or diabetes at the time of
    discharge.
    The authors derived weights to calculate S-Elixhauser comorbidity scores
    for hospitalization, 30-day, and 1-year mortality.
    Results for short- and long-term mortality are then internally validated and calibrated
    for all older adults and patients hospitalized for three specific diagnoses.
    The authors also conducted external validation
    of the Charleson and AHRQ Elixhauser comorbidity scores in predicting mortality in older adults.
    According to the authors, internally validated S-Elixhauser discriminatory measures were much better than external validation measures from other scores, and when there were externally validated S-Elixhauser, they expected this difference to diminish or disappear
    .

    Media Contact: For access to the banned PDF file, please contact Angela Collom at acollom@acponline.
    org
    .
    Contact the corresponding author, Dr.
    Hemalkumar B.
    Mehta, and send an email to JHMedia@jhmi.
    edu
    .
    ----------------------------
    3.
    Over the past 20 years, the turnout of medical professionals has been about
    20 percent lower than that of the general population.
    When asked why they didn't vote, doctors often mention busy schedules, lack of voter registration, and feeling that their individual votes were not important
    .
    To address this, a team of researchers from Harvard Medical School and the University of Texas Southwestern Medical Center developed a four-step framework to increase turnout among healthcare professionals, and specific actions
    that individuals and health systems can take.
    The framework was published in the Annals of Internal Medicine
    .
    According to the researchers, it's important for health professionals to vote because the health policies of electing officials directly affect their careers and the patients
    they serve.
    The authors say there are 4 key steps to mobilizing medical professionals to vote: registration, which includes encouraging and helping medical professionals to register to vote in their districts; Non-partisan education to keep them informed about topics and candidates' positions; Communicate with friends and family to plan when and where to vote while increasing social responsibility; Simplify the process and address common obstacles to voting, such as taking time off to vote
    .

    The researchers provided detailed action
    on how individuals and health systems can be involved in each of these four steps.
    Adopting this simple 4-step framework, they argue, could help reinvigorate civic engagement among healthcare professionals so they can more easily voice their views on key health policy issues
    .

    Media Contact: For access to the banned PDF file, please contact Angela Collom at acollom@acponline.
    org
    .
    Contact the corresponding author, Hussain S.
    Lalani, MD, MPH, and send an email to hlalani@bwh.
    harvard.
    edu
    .
    ---------------------------- also new on this subject: deep vein thrombosis Lisa Duffett, Medical Yearbook in clinical article:

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